Study of invasive and non-invasive methods to detect h pylori infection
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 12
Abstract
Introduction: As per epidemiology at least half the world's population is infected by H.pylori making it the most widespread infection in the world, Actual infection rates vary from nation to nation. The Third World has much higher infection rates than the West (Western Europe, North America, Australia), where the rates are estimated to be around 25%. Aims and Objectives: To Study of Invasive and Non-Invasive Methods to Detect H Pylori Infection. Methodology: The present study was carried out in the Department of Pathology in a tertiary care hospital in Tamil Nadu. This was a Prospective study. Total 105 cases were studied, Detection of Helicobacter pylori done by Rapid Urease Test, Serological tests, Histopathological examination. Result: Out of 105 patients, 86 [81.9%] patients were positive for H.pylori by rapid urease test. Out of the 105 cases, 90 [85.7%] patients were positive for H.pylori by serological method. The observed cut-off value was 0.516. Histopathologically, 60 cases (57.1%) showed evidence of chronic active gastritis, of which 58 cases (96.7%) were H.pylori positive. The sensitivity, specificity and accuracy of rapid urease test are 93.24%, 45.16% and 79.05% respectively. The sensitivity, specificity and accuracy of serologic testing are 98.65%, 45.16% and 82.86% respectively. Conclusion: Histopathological examination is the gold standard test for H.pylori detection against which the sensitivity, specificity and accuracy of serologic testing are 98.65%, 45.16% and 82.86% respectively and The sensitivity, specificity and accuracy of rapid urease test are 93.24%, 45.16% and 79.05% respectively.
Authors and Affiliations
K M Selvanayaki, R Palanisamy
Keywords
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