Study of Lactic Acid Level in Cerebro-Spinal Fluid And It’s Prognostic Significance in Patients of Cerebral Malaria
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
IntroductionCerebral malaria is defined as a diffuse cerebral encephalopathy, characterized by unarousable coma in the absence of any other attributable cause of unconsciousness (i.e. meningoencephalities, stroke, head injury, heat stroke, metabolic encephalopathies etc.) in a patient having plasmodium falciparum infection. Materials and methods • The present study “study of lactic acid level in cerebro-spinal fluid and its prognostic significance in patients of cerebral malaria” was carried out in the Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi. • Study Design:- Prospective observational study • Sample Size:- 80 • Study Period:- Oct. 15 to Oct. 16 Result:-Increased CSF lactic acid was found in 100% cases of cerebral malaria. The mean level of CSF lactic acid at presentation was found to be higher in fatal cases than in the survivors. The mean level in fatal cases was 66.62mg/dl while in survivors, it was 39.17 mg/dl.CSF lactic acid level more than 54mg/dl (double than normal) were associated with higher mortality (80% while 20% patients survived in this group). On the other hand, CSF lactic acid level less than 54 mg/dl were associated with low mortality (13.33%).{P<0.05} Conclusion:- Cerebral malaria is a medical emergency with very high mortality ,30% mortality in this study .CSF lactic acid generally rises above the normal range in almost all cases of cerebral malaria.Significantly raised CSF lactic acid (>54 mg/dl) is associated with bad prognosis and poor chances of survival, unless energetic and efficient management is done to save the patient. Significantly raised CSF lactic acid (>54mg/dl, double than the normal) level was associated adverse prognostic indicators of cerebral malaria.
Authors and Affiliations
Dr. Umesh Prasad, Dr. Ashish chand, Dr. Jag Mohan Kumar
Keywords
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- EP ID EP598988
- DOI 10.9790/0853-1603081722.
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