Study of Leukopenia as haematological parameter, to find it’s diagnostic rationale in dengue patients
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 4
Abstract
Introduction The dengue fever is in the form of epidemic in India which occurs usually after rainy season There is need of adjuvant haematological parameters that can at very initial stage differentiate the dengue fever from other viral fever which are prevalent at the same timeAims and Objectives This retrospective study was carried out to find association of leukopenia with dengue fever As screening test for dengue fever are not available in remote areas so we had tried to access diagnostic power of leukopenia in dengue fever along with thrombocytopeniaMaterials and Methods Total 520 cases had been taken Out of these 220 cases were positive for dengue fever as confirmed on dengue fever ELISA test for NS1 andor IgM Retrieved data were analysed for platelet counts and total leukocyte countsResults In Total 220 cases of dengue fever 101 cases had shown both leukopenia and thrombocytopenia While in 300 normal cases there were only 2 cases of leukopenia along with thrombocytopenia The sensitivity of leukopenia alone for diagnosis of dengue fever was only 5091 but the specificity was 9833 Positive Likelihood Ratio PLR of leukopenia to dengue fever was 3055 Although the sensitivity was decreased to 4591 if leukopenia with thrombocytopenia was used as diagnostic tool for dengue fever but specificity was increased up to 9933 with PLR up to 6886 The total leukocyte count and platelets were statistically reduced with extreme significance P pConclusion The leukopenia alone is highly specific for dengue fever but if combined with thrombocytopenia specificity is further increased Both Leukopenia and thrombocytopenia were statistically extremely significant P KeywordsDengue fever Leukopenia ELISA Platelet countThrombocytopenia
Authors and Affiliations
Jagjeevan Ram,, Manoj Kumar Gupta, Poonam Rani, Kamlesh Kumar, Amrita Dr
Keywords
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- EP ID EP475930
- DOI 10.18231/2394-6792.2018.0116
- Views 62
- Downloads 0
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