Study of ointment base influence over biopharmaceutical characteristics of praziquantel semisolid dosage form for external use
Journal Title: Фармацевтичний журнал - Year 2016, Vol 5, Issue 5
Abstract
Problem of acne dermatosis, complicated with demodicosis pharmacotherapy is one of the topical for the domestic dermatology because of a number of antidemodicosis medications isn’t large and almost all of the most effective are imported. Praziquantel is an antiparasitic medication which also has an antidemodicosis activity and a low toxicity according to domestic experimental data and is registered in Ukraine in tablet form. Because of that, developing praziquantel semisolid dosage form – ointments for the local and system etiotropic therapy of acne dermatosis, complicated with demodicosis is a topical problem for the modern pharmaceutical and medical science. It will allow to increase an arsenal of the domestic dermatologic medications and will create the real alternative to imported pharmacotherapeutical dosage forms. The aim of this work is carrying out investigations of the substantiation of optimal base for the semisolid dosage form. Researches were carried out by the one-factor dispersive method with repeated observations. For all of the selected compositions praziquantel releasing was determined as the first stage of bioavailability evaluation. Praziquantel releasing from the ointments was studied with equilibrium dialysis method by Kruvchinsky in the Franz cell apparatus. As a dialysis medium was used ethyl alcohol taking into account praziquantel solubility. It was ascertained that sort of the base exerts significant influence on the praziquantel releasing from the ointments for external use. Variance analysis revealed that the optimal praziquantel releasing from the ointments is provided with emulsion oil/water base.
Authors and Affiliations
D. M. Romanina, I. I. Berdey, V. V. Gladishev, G. P. Lisyanska
Keywords
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