Study of Oxidative Stress in Hypercholesterolemia
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 5
Abstract
Introduction: Oxidative stress is an imbalance between free radicals formation and their scavenging (antioxidant system) in the body. In hypercholesterolemia, there is an increase of total cholesterol pool in cells which results into altered cell membrane due to lipid peroxidation. It is due to leakage of lipid peroxides and other free radicals from cell membrane. MDA is the marker of lipid peroxidation generating peroxides and other free radicals. RBCs are most vulnerable to oxidative stress leading to their hemolysis. SOD (Superoxide dismutase) is the marker enzyme of antioxidant systems making free radicals inactive. RBCs hemolysis, SOD and MDA has been used as the study markers of oxidative stress in case of hypercholesterolemia. Material and Methods: Both the control and hypercholesterolemic subjects (50 in each category) were chosen from medical OPD for this study. Blood sample was taken with their consent for estimation of total cholesterol, Percentage hemolysis of HBs (before and after incubation with H2O2), SOD and MDA. Result: Mean cholesterol level in hypercholesterolemic subjects was 325.30±11.20 in comparison to controls(141.20±5.40). Mean values of percentage hemolysis of HBs and MDA were found increased with significantly decreased SOD in hypercholesterolemic subjects in comparison to controls. Conclusion: In the study RBCs hemolysis and MDA (malondialdehyde) are found increased whereas SOD is found decreased which indicates increased oxidative stress. Thus the study concludes that oxidative stress is found increased in hypercholesterolemia
Authors and Affiliations
Uday N Singh, Subodh Kumar, Sanjeev Dhakal
Keywords
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