Study of Oxidative Stress in Hypercholesterolemia

Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 5

Abstract

Introduction: Oxidative stress is an imbalance between free radicals formation and their scavenging (antioxidant system) in the body. In hypercholesterolemia, there is an increase of total cholesterol pool in cells which results into altered cell membrane due to lipid peroxidation. It is due to leakage of lipid peroxides and other free radicals from cell membrane. MDA is the marker of lipid peroxidation generating peroxides and other free radicals. RBCs are most vulnerable to oxidative stress leading to their hemolysis. SOD (Superoxide dismutase) is the marker enzyme of antioxidant systems making free radicals inactive. RBCs hemolysis, SOD and MDA has been used as the study markers of oxidative stress in case of hypercholesterolemia. Material and Methods: Both the control and hypercholesterolemic subjects (50 in each category) were chosen from medical OPD for this study. Blood sample was taken with their consent for estimation of total cholesterol, Percentage hemolysis of HBs (before and after incubation with H2O2), SOD and MDA. Result: Mean cholesterol level in hypercholesterolemic subjects was 325.30±11.20 in comparison to controls(141.20±5.40). Mean values of percentage hemolysis of HBs and MDA were found increased with significantly decreased SOD in hypercholesterolemic subjects in comparison to controls. Conclusion: In the study RBCs hemolysis and MDA (malondialdehyde) are found increased whereas SOD is found decreased which indicates increased oxidative stress. Thus the study concludes that oxidative stress is found increased in hypercholesterolemia

Authors and Affiliations

Uday N Singh, Subodh Kumar, Sanjeev Dhakal

Keywords

Related Articles

A Comparative Study of Brainstem Evoked Response in Patients with Diabetic and Nondiabetic Subjects

Introduction: Diabetes mellitus (DM) causes pathophysiological changes at multiple organ system. With evoked potential techniques, the brain stem auditory response represents a simple procedure to detect both acoustic ne...

Assessment of Risk of Development of Hypertension among Obese People: A Retrospective Study

Introduction: One of the risk factors which is hypothesized to increase the risk of development of hypertension is obesity. Among Asian population, several studies have shown that obesity is one of the risk factors for d...

Role of C-Reactive Protein in Periodontal Disease – A Review

CRP is an acute-phase reactant that is produced in response to diverse inflammatory stimuli including heat, trauma, infection, and hypoxia. Serum CRP levels provide useful information for the diagnosis, monitoring and th...

Perinatal and Maternal outcomes of Eclampsia in Darbhanga District, Bihar, India

Introduction: Pre-eclampsia is characterized by new-onset hypertension and proteinuria at ≥20 weeks of gestation. In India, the perinatal mortality of neonates of eclamptic mothers is also very high to the extent of abou...

Functional Outcome of External fixator in Intra Articular Distal Radius Fractures

Introduction: Fractures involving the distal end of radius are one of the most common injuries encountered in Orthopaedics. 90% of these fractures were treated with closed reduction and cast application. The aim of this...

Download PDF file
  • EP ID EP428341
  • DOI -
  • Views 112
  • Downloads 0

How To Cite

Uday N Singh, Subodh Kumar, Sanjeev Dhakal (2017). Study of Oxidative Stress in Hypercholesterolemia. International Journal of Contemporary Medical Research, 4(5), 1204-1207. https://europub.co.uk./articles/-A-428341