Study of paediatric renal biopsies with clinicopathologic correlation and comparison with literature on adult renal biopsies
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Renal biopsy is frequently used in complete workup for renal diseases The kidney reacts in a limited number of patterns to various injuries and the clinical manifestations corresponding to these reactions are also limitedAim of the study To study the nonneoplastic renal diseases in paediatric population 015 year age to study the differences in the disease prevalence between paediatric and adult population and to document the geographic variation in renal diseasesMaterials and Methods The renal biopsies from 015 year age group of both genders were studied for light microscopy and immunofluorescence studies The clinical presentation of the patients such as nephrotic or nephritic or both or as acute renal failure was noted for clinic pathologic correlation The paediatric renal diseases were compared with adult renal diseases based on literature search Also the geographic variations were studied and compared based on published data from different countriesResults Nephrotic syndrome was the most common clinical presentation for paediatric renal diseases Minimal change disease 378 and FSGS 224 cases commonly presented as nephrotic syndrome PIGN 376 cases presented frequently as nephritic syndrome in the paediatric age groupConclusion Nephrotic syndrome is the most common indication for renal biopsy and minimal change disease is the commonest cause of nephrotic syndrome in children Incidence of membranous nephropathy and IgA nephropathy is relatively less in India PIGN is the most common cause of acute renal failure in the paediatric age group In systemic lupus erythematosus most common presentation is nephrotic syndrome with class IV lupus nephritis being more frequentKeywords Acute renal failure IgA nephropathy Nephrotic syndrome Nephritic syndrome Paediatric age group Renal biopsy
Authors and Affiliations
Kirti Khetan, Gunjan Gupta, Swarnalata G.
Keywords
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- EP ID EP473192
- DOI 10.18231/2394-6792.2018.0018
- Views 65
- Downloads 0
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