Study of Portal Hemodynamic Changes Using Doppler Ultrasound in Egyptian Cirrhotic Patients with Oesophageal Varices Treated By Band Ligation with or Without Beta Blockers Portal Hemodynamics In Egyptian Cirrhotics
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 10
Abstract
Background and aims: Egypt has the largest burden of hepatitis C infection & liver cirrhosis worldwide. Sixty percent of cirrhotic patients develop esophageal varices and thirty percent suffer variceal hemorrhage. Studying portal hemodynamics using duplex Doppler is non-invasive, reliable and relatively cheap method for evaluating portal hemodynamic changes in cirrhotic patients; also it can be used in studying the effect and prognosis of different drugs used to reduce portal hypertension. Whereas Baveno Consensus conference recommends β-blockers, banding ligation or both; the experts add that combined therapy is probably the best. Aim Of The Work: was to study portal hemodynamics in cirrhotic patients with esophageal varices admitted for band ligation with and without the administration of propranolol. Patients And Methods: 50 patients eligible for the study (cirrhosis, esophageal varices and no contraindications for propranolol), were randomized into two groups: Group I: 25 patients on oral propranolol (non-selective β-blocker) combined with endoscopic variceal band ligation. Group II: 25 patients on endoscopic variceal band ligation alone without oral propranolol. RESULTS: As regards to Portal vein diameter (PVD), Portal vein flow velocity (VEL), and Congestion index (CI), there was no statistically significant difference between the two groups before the start of the treatment. After 6 months of treatment, there was statistically significant difference between the two studied groups as regards to PVD & VEL, while non-statistically significant difference for CI. Conclusions: both band ligation and propranolol reduced portal hemodynamic parameters, but patients on combination of both showed better results.
Authors and Affiliations
Mohamed Tamer Afifi
Keywords
Related Articles
- EP ID EP212706
- DOI -
- Views 67
- Downloads 0
To study knowledge, attitude and actual practices regarding Mahatma Jyotiba Phule Jan Arogya Yojana at tertiary care hospital of MaharashtraA cross sectional study
MJPJAY is a state sponsored publically funded health insurance scheme (PFHI) launched by Govt. of Maharashtra. It provides free quality critical care for low income families. At tertiary care hospital, specialist is the...
Clinical predictors of mortality in non traumatic coma: A prospective observational study
Background: Coma developed during ongoing course of an illness commonly result in poor prognosis. Early prognostication is crutial for treatment decisions. This study has been conducted to ascertain the clinical predicto...
Medications Used Before and After Cataract Surgery in A Tertiary Care Hospital
Introduction: Cataract is the most common ocular disease, which is characterized by opacification of lens resulting in gradual progressive diminution of vision. Drug utilization research contributes to the rational drug...
Open reduction and internal fixation of talar fractures using various approaches and its outcome: A case series study
Introduction: Talus fractures are common in injuries of high-energy mechanisms and also with other musculoskeletal injuries and systemic trauma. Treating talus fracture in the multiple injured patient is a challenge. Var...
Pathology of Post Meningitic Hydrocephalus
Meningitis of Bacterial (Including Tubercular) or non bacterial origin is common and lethal infection of central nervous system in children. Although with the use of modern medical facilities including antibiotics the mo...