STUDY OF RENAL OSTEODYSTROPHY IN CHRONIC KIDNEY DISEASE
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 1
Abstract
The kidney plays an important role in the mineral metabolism; in addition to being a target organ for various hormones involved in calcium and phosphorus metabolism, the kidney is the main organ that activates vitamin D. Thus, it is quite understandable that kidney dysfunction can result in derangement of mineral metabolism. Ever since the first report of severe osteitis fibrosa cystica with parathyroid hyperplasia, this disorder was considered to be a skeletal/bone disease and was named “renal osteodystrophy”. The clinical management of renal osteodystrophy, therefore, primarily aimed to maintain parathyroid hormone (PTH) levels appropriate for normal bone metabolism. Traditionally, when defining bone diseases in CKD patients, this group of disorders has been usually termed renal osteodystrophy. However, beside strictly defined, the term renal osteodystrophy means only bone abnormalities. Recently, the KDIGO (Kidney Disease: Improving Global Outcomes) (1) conference group agreed that the definition of renal osteodystrophy should be only specific to bone pathology found in patients with CKD. It has been concluded that renal osteodystrophy is one component of the mineral and bone disorders that occur as a complication of CKD. It has been proposed that the evaluation and definitive diagnosis of renal osteodystrophy requires performing a bone biopsy. Histomorphometry is not essential for clinical diagnosis, but should be performed in research studies. Key words: Chronic kidney disease, Osteodystrophy, Renal
Authors and Affiliations
Ashit Rameshchandra Patel, R R Mane, R J Khyallapa
Keywords
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