Study of serum lactate dehydrogenase and lipid profile in patients with chronic cough
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 4
Abstract
Background: Lactate dehydrogenase (LDH) enzyme is found in almost every tissues of the body and its level is increased in serum in many tissue damaging pathological disorders. Patients with chronic cough mostly have history of cigarette smoking and prone to airway inflammation. Documentary studies shows cigarette smoking is associated with altered lipid profile. The aim of the present study is to assess whether there is alteration in the concentration of serum lactate dehydrogenase and lipid profile in patients with chronic cough by estimation of lactate dehydrogenase level and lipid profile in serum. Material and Methods: It is a case control study consisting of 50 cases with chronic cough compared with 50 healthy controls. Serum level of lactate dehydrogenase, total cholesterol, and triglyceride, LDL, VLDL and HDL were estimated in both the study groups. Statistical analysis was done by using unpaired t test. Values were expressed as means and standard deviation (SD). Results: Statistically significant increase in the levels of LDH was found in patients with chronic cough as compared to controls. Serum levels of LDL were increased significantly in cases as compared to controls. Serum levels of cholesterol, triglyceride VLDL and HDL were not altered in cases as compared to control. Conclusion: Serum LDH level was increased in patients with chronic cough which may be due to respiratory tract inflammation commonly caused by smoking. Increased level of LDL in patients with chronic cough is significantly correlated with smoking.
Authors and Affiliations
Mahesh Basavaraj Madole, Dilip Bhave, Mamatha MT, Ankur Patel
Keywords
Related Articles
- EP ID EP243018
- DOI -
- Views 106
- Downloads 0
The synergistic role of CKMB mass and high sensitivity Troponin T in the diagnosis of Acute Coronary Syndrome
Aim: To determine the synergistic role of CKMB mass (CKMBM) and high sensitivity Troponin T (hs-cTnT) in the diagnosis of Acute Coronary Syndrome (ACS). Study Design: This was a cross-sectional study comprising of 140 in...
Cross sectional comparative study of serum free iron in type 2 diabetes mellitus patients with and without retinopathy and nephropathy complications
Introduction: Non protein Bound iron has the capacity to generate reactive oxygen species is called Free iron causing lipid peroxidation and protein oxidation. Free radicals have been implicated in the pathogenesis of di...
Serum gamma glutamyl transferase and hs-CRP levels in patients with type 2 diabetes mellitus
Introduction: Type 2 diabetes mellitus and its complications is an important health problem. As oxidative stress and inflammation appears to play a major role in the pathogenesis of diabetes mellitus and development of i...
Biochemical markers for early detection of cardiovascular disease in smokers
Introduction: The prevalence of coronary heart disease (CHD) is increasing in urban as well as rural areas in India especially during the last decade due to adoption of smoking habits. Tobacco smoking is currently ranked...
Cerebrospinal Fluid Adenosine Deaminase Activity: A Valid Ancillary Test for Tubercular Meningitis
Background: Tuberculosis affects 1.80 million persons every year with 3.70 lakh annual deaths, ~ 10% of which are of meningeal involvement. Diagnosis of Tubercular meningitis is difficult with often under or over diagnos...