Study of skin prick test, total IgE, blood eosinophil and exhaled nitric oxide (FENO) for classifying allergic or non-allergic asthma and for asthma management
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2018, Vol 9, Issue 29
Abstract
Background. Asthma is a common respiratory disorder, characterized by local infiltration and activation of a variety of inflammatory mediators and cells. In allergic asthma, increased blood or tissue eosinophilia, total concentration or specific IgE, fraction exhaled nitric oxide are frequently reported. Method. It was a prospective study on 67 asthmatic patients. Eosinophil count, IgE concentrations, lung function, and measurements of nitric oxide in exhaled breath (FENO) were done. The patient had positive skin prick test were classified as allergic asthma patients and patients with negative skin prick test were considered as non-allergic asthmatic patients. Results. More than 70% of patients had a history of allergy, in which allergic rhinitis is the most common comorbidity. Positive skin test of Df, Dp and Blomia house dust mites were higher. Total IgE and blood eosinophil level were high than normal limit. FENO concentrations were higher in allergic asthmatic patients. All asthmatic patients had a good response to ICS with moderate to high doses. The asthma control was achieved after 6 months of standard treatment. Conclusion. Asthmatic patients have mainly allergic characteristics with increased inflammatory biomarkers, especially FENO level. Therefore, the use of FENO is useful for management of asthma.
Authors and Affiliations
Sy DUONG-QUY
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- EP ID EP570776
- DOI 10.12699/jfvpulm.9.29.2018.38
- Views 74
- Downloads 0
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