STUDY OF SOME BIOCHEMICAL VARIABLES OF CARDIOVASCULAR PATIENTS AND EFFECT OF SOME PRODRUGS ON THE ACTIVITY OF SOME ENZYMES IN VIVO AND IN VITRO
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2018, Vol 3, Issue 2
Abstract
Several studies have shown the risk factors associated cardiovascular disease (CVD). This research studies some biochemical variables of Cardiovascular patients and effect of some prodrugs on the activity of some enzymes in vivo and in vitro . in this study we estimate some biomarker for cardiovascular patients CKMB ,LDH ,GPT ,GOT ,Cholesterol ,TG ,HDL ,LDL, VLDL, MDA ,Vitamin C and Vitamin E. Blood samples were collected from 50 cardiovascular patients (25 males and 25 females) and 50 healthy control (25 males and 25 females) from Tikrit hospital, Tikrit city Iraq. Ages of the involved subject range were from 33 to 65 years. Our result show a highly signicant increase (p < 0.005) in the serum levels of CK-MB , LDH , cholesterol, triglyceride , HDL-cholesterol , GOT ,GPT, MDA in comparison with the control group and signicant decrease in Alb ,HDL-Cholesterol ,Vitamin C and vitamin E in comparison with the control . No signicant differences between gender (males and females) and no signicant differences between ages. Inhibitory effect was study of some prodrugs on CK-MB and LDH activities in serum . The results revealed that the prodrugs have an inhibition effect on the CK-MB and LDH activities with higher inhibition range. The inhibition increased with the increasing concentration of prodrugs while the type of inhibitor showed noncompetitive inhibition. This study was conducted (in vivo) for Ascorbic acid prodrug )Ascorbic acid –Indomethacine( (1) and Glucose prodrug (glucose – Ibuprofe) (2). The concentration of Ibuprofen and Indomethacine was measured in serum after (2, 3, 4, 6, 8, 10) hours of giving a dose to the animal. The results showed that the concentration of Ibuprofen and Indomethacine were the highest after six hours of giving the animal dose. Biochemical study showed inhibition in enzyme activity for prodrugs1 and 2.
Authors and Affiliations
Firas Taher Maher
Keywords
Related Articles
- EP ID EP598241
- DOI -
- Views 50
- Downloads 0
WIDE COMPLEX TACHYCARDIA IN ADULT PATIENT WITH EBSTEIN'S ANOMALY: WHAT IS THE MECHANISM?
We present the case of a 60-year-old female with a history of Ebstein's anomaly diagnosed at childhood admitted to our hospital for wide complex tachycardia. Programmed ventricular stimulation was negative. Electrophysio...
PRIMARY IMMUNODEFICIENCY DISORDERS IN SOUTHERN IRAN
Background: There are great diversities in the frequency of different types of Primary immunodeciency disorders (PIDs) in between various races and geographic regions. This study was designed to gather epidemiologic inf...
CORRELATION OF CLINICAL EXAMINATION, MAMMOGRAPHY AND HISTOPATHOLOGY EXAMINATION IN TUMOUR STAGING FOR CARCINOMA OF BREAST - TERTIARY INSTITUTIONAL STUDY, INDIA.
Background: The cancer breast is most common malignancy among the rural as well as urban women in India. This study aimed at to correlate tumor size by clinical breast examination (CBE), mammogram and post-operative hist...
COLONIZATION BY GROUP B STREPTOCOCCUS AND ANTIMICROBIAL RESISTANCE PATTERNS IN KUWAIT: AN OBSERVATIONAL STUDY IN 2014 AND 2016
BACKGROUND: We determined the colonization rate of Group B streptococcus (GBS) and the antibiotic resistance proles among pregnant women in Kuwait, and established the association between the colonization rate and age g...
STATIN INDUCED MYOPHATY. CASE REPORT
We present the case of a 28-year-old woman, who began suffering 6 months prior to admission with weight loss, malaise, dysphagia to solids and progressive dyspnea. Anterior mediastinoscopy and lymph node biopsy were perf...