STUDY OF SYNTHETIC FORM OF TOMATO LYCOPENE AND ITS EFFECTIVELY OVER NATURAL AND PLACEBO FORM OF LYCOPENE IN PATIENTS WITH OXIDATIVE STRESS
Journal Title: GJRA-Global Journal For Research Analysis - Year 2019, Vol 8, Issue 2
Abstract
Objective- Lycopene is a phytochemical, found in tomatoes having singlet oxygen quenching ability higher than other antioxidants, participates in most of chemical reactions to protect critical cellular biomolecules. Present study is to analyze effect of tomato's lycopene, synthetic lycopene, its placebo form in patients of oxidative stress. Methods- Study includes 45 patients having oxidative stress, aged 40-60 years and 30 age and sex matched healthy controls. Blood samples were collected at the time of enrollment, end of 2 weeks of lycopene restricted diet and after 10 weeks of lycopene supplementation. Oxidative stress biomarkers MDA, SOD, vitamin C and E were measured. Results- Results of study revealed decreased lipid peroxidation and oxidative stress after various forms of lycopene supplementation but comparative analysis showed significant increase in oxidative stress biomarkers except MDA in patients receiving synthetic lycopene in comparison with natural and placebo forms of lycopene. Conclusion- Dietary intake of tomato lycopene (natural) is beneficial to fight against OS but in the synthetic form it is more bioavailable and directly effective against OS.
Authors and Affiliations
Dr Trapti Gupta, Dr Ashok Sahu
Keywords
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