Study of the Central and Peripheral Autonomic Function in Short Evolutions Type 2 Diabetes and it’s Risk Categories

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Study of the Central and Peripheral Autonomic Function in Short Evolutions Type 2 Diabetes and it’s Risk Categories

Journal Title: Diabetes Research – Open Journal - Year 2015, Vol 1, Issue 1

Abstract

for type 2 diabetes (prediabetes) to recently established type 2 diabetes. Research Design and Methods: It is a longitudinal, prospective and observational study (population consisting in 30 control subjects, 30 patients with increased risk for type 2 diabetes and 30 patients with type 2 diabetes ≤8 years of evolution. Study was carried out by designing a modified battery of Ewing. To study autonomic: resting Heart Rate (HR), deep inspiration, controlled breathing, 30/15, Valsalva maneuver, Sustained handgrip test (SHGT) and prolonged QTc indexes) and to study sudomotor: measurement of the Skin Conductance Response (SCR) deep inspiration, controlled breathing, standing to orthostasis, Valsalva maneuver and SHGT. The ECG and the Electrodermal response signal (EDR) was recorded while the patients execute the tests. Results: Results were statistically analyzed by taking into account the group the patients belonged to, their anthropometric variables (directly measured) and their results from blood tests. Obtained results allowed us to determine the order in which every autonomic index passes from normal to abnormal and the corresponding nerve fibers involved. Cardiac autonomic variables: resting HR: it is average value increases as the dysglicaemia progressed, significant differences were only found between the control and the type 2 diabetes group (p=0.041). Deep inspiration index: significant differences were only found between the increased risk group and the type 2 diabetes group (p=0.047). 42.9% of the control subjects, 39.1% of the increased risk patients and 59.3% of type 2 diabetes presented anomalous values for this index. Controlled breathing rate: significant differences were only found between the control group and the type 2 diabetes group (p=0.008). 7.1% of the control subjects, 31.8% of the increased risk patients and 34.6% of type 2 diabetes presented anomalous values for this index. Significant differences were only found between the control group and the increased risk group (p=0.023). Sudomotor autonomic variables: no significant differences were found between the groups for the average value of SCR, or anomalous values of SCR to the various autonomic stimuli studied. SCR-HR: we found significant correlation between the sudomotor response generated by the SHGT maneuver and the variation of the HR generated by this autonomic stimulus (p=0.036); not so for the remaining stimuli. Conclusions: CAD appears to be the first manifestation of DAN and is already present in prediabetes and short evolution type 2 diabetes. This finding suggests an early impairment of parasympathetic fibers in disglycemic patients, and may help design preventive strategies aimed to avoid the severe complications related to this entity.

Authors and Affiliations

F. Javier Pagan Buzo

Keywords

Central and Peripheral Autonomic Function. Type 2 Diabetes. Risk Categories.

EP ID EP549353
DOI 10.17140/DROJ-1-103
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