Study of Various Histopathological Lesions of Prostate and Their Correlation with Serum Prostate Specific Antigen.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 3
Abstract
Background: Carcinoma of the prostate is most common non skin cancer in the west and the second leading cause of cancer death among men. In India, carcinoma of prostate occupies 2nd to 10th rank among cancers in men. The present study includes description of incidence of various lesions of prostate, their clinical manifestations, serum PSA level, classification, and grading of prostate tumors. Methods: The present study was conducted 226 prostatic needle biopsies in Department of Pathology, S. P. Medical college, Bikaner. Materials for the study consisted of prostate needle biopsies. The section were examined for histomorphological characters of prostate and clinical history was taken. The PSA levels were estimated. After studying the histopathological features, the diagnosis of various types of prostatic lesions was made and Gleason’s scoring was done in cases of prostatic carcinoma. Subsequently, a correlation was made between the histopathological diagnosis and serum PSA level. Results: Disease was prevalent in 7th and 8th decade of life with most common type of lesion was benign followed by malignant. Majority of 55% of benign lesions were found to be associated with serum PSA level <4ng/ml and 31.5% malignant lesion were found to be associated with serum PSA level 20.1-40.0 ng/ml. Most common gleason score was 7. Conclusion: In conclusion benign prostatic hyperplasia is the most common pathology encountered in prostatic specimens. PSA is specific for prostatic tissue and is raised in both benign and malignant lesions of prostate.
Authors and Affiliations
Subhash Chandra Dhayal
Keywords
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