Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 2
Abstract
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder showing an increasing trend with an increase in complications such as diabetic retinopathy (DR), which can cause blindness. Most patients do not notice vision loss early; hence, it is beneficial to have dysfunction of the retina identified. Patients with T2DM and DR have shown abnormalities in visually evoked potentials (VEPs). Objectives: To investigate whether VEPs can be used to detect early changes related to T2DM and DR. Materials and Methods: A total of 111 patients, of both sexes and aged 40-70 years, were studied as three groups of 37 each, who were, respectively, patients with T2DM, patients with DR, and normal subjects. For all the groups, VEP recording was done using Medicaid Neurostim EP machine, and retinal examination was done using direct ophthalmoscopy. The latency and amplitude of P100 in VEP of both eyes were, respectively, analyzed using analysis of variance and post-hoc test. Results: Our results showed significantly prolonged P100 latencies of VEPs in T2DM patients and DR patients when compared to controls. However, there was no a significant difference observed in the P100 amplitudes of VEPs in T2DM patients and DR patients when compared to controls. Conclusion: The present study has highlighted the importance of VEP as a valuable non-invasive test to detect early neuronal changes in T2DM patients and can be recommended for monitoring early effects of diabetes on visual function.
Authors and Affiliations
Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass
Keywords
Related Articles
- EP ID EP288256
- DOI 10.5455/njppp.2017.7.0824424082016
- Views 73
- Downloads 0
Correlation between serum free iron, glycated hemoglobin and insulin resistance in uncontrolled type-2 diabetic patients
Background: The link between iron and diabetes was first recognized in pathologic conditions—hereditary hemochromatosis and thalassemia—but high levels of dietary iron also impart diabetes risk. Free iron may contribute...
Molecular, biochemical, and pathological impacts of energy drinks on renin–angiotensin–aldosterone pathway in Wistar rats
Background: Energy drinks (EDs) are widespreaded among young adolescents and adults to enhance physical and mental performance with numerous public health hazards. Aims and Objective: This study was conducted deeply to e...
Study of potential drug–drug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region
Background: Drug–drug interactions (DDIs) are very common and responsible for 6%–30% of the adverse drug events that will increase healthcare cost and patient outcome. Polypharmacy significantly contributes to DDI...
The requirements of the caregivers of patients hospitalized in intensive care units
Background: Following the hospitalization of a family member in the ICU, new needs are created in the family members, and if these requirements are not met, a lot of stress and anxiety is created in the members and reduc...
A study of mental distress in medical students
Background: Mental distress is de fi ned as unpleasant mental or emotional state, often impairing one ’ sabilitytocope with day-to-day living. The undergraduate medical training is a stressful period and medical st...