Study on Correlation between Endocrine and Metabolic Parameters in Polycystic Ovary syndrome and Thyroid-Stimulating Hormone: Should Normal Thyroid-Stimulating Hormone Level be Redefined?
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 3
Abstract
Introduction: Polycystic ovary syndrome (PCOS) is a fairly common disorder of women in the reproductive age. Thyroid-stimulating hormone (TSH) affects endocrine and metabolic parameters in PCOS are claimed by some researchers. Purposes: This study was carried out to clarify if there are correlations with endocrine and metabolic parameters in PCOS with TSH. Methods: A total of 100 PCOS patients of age group between 20 and 35 years and body mass index (BMI) 18.5-30kg/m2 were recruited. Forty (n=40) healthy female subjects matched for age and BMI were also enrolled as controls. Cases were divided into two groups: Group I (TSH<2.1) and Group II (TSH≥2.1). All variables were again compared between two groups of PCOS cases. Results: The mean serum BMI, TSH, fasting glucose, fasting insulin, homeostatic model assessment-insulin resistance, total cholesterol, low-density lipoprotein, triglyceride, and very low-density lipoprotein levels were significantly higher in Group II PCOS than Group I PCOS. Moreover, the luteinizing hormone (LH) and LH/follicle-stimulating hormone (FSH) levels were significantly lower in the patients with Group II PCOS than Group I PCOS (P< 0.05). Serum FSH, total testosterone, and high-density lipoprotein were unaltered in both groups. Conclusion: TSH altered endocrine and metabolic parameters in PCOS.
Authors and Affiliations
Md. Sadique Mallick, Serina Khatun
Keywords
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