“Study on The Effectiveness of Iron, Folic Acid, Vitamin B Complex And C for Reducing The Risk of Pre-Mature Ruptures of Membrane in Pregnancy”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Background: Preterm premature rupture of membranes (PPROM) is one of the most important complications of the pregnancy and cause perinatal morbidity and mortality. Iron, Folic acid, Vitamin B Complex and Vitamin C plays an important role in collagen metabolism and increases resistance maintenance of the chorioamniotic membranes. Objectives: The aim of this study is to assess the effectiveness of Iron, Folic acid, Vitamin B Complex and Vitamin C for reducing the risk of Pre-mature Ruptures of membrane in pregnancy. Patients and Methods: This clinical trial study was performed on 200 pregnant women with the history of PPROM, with singleton pregnancy and gestational age 14 weeks in a hospital in Dhaka City during February 2015 to January 2016. They were randomly divided into two groups. in the case group, 100 women prescribed 400µg folic acid daily in the first trimester, then iron tablet containing 30 mg elemental iron , chewing tablet of 100 mg vitamin C, Vitamin B complex daily were added from 14th weeks of gestation [ and was continued up to 37th weeks and control group, 100 patients were treated similar except for chewing tablet of placebo insist of same shape of structured questionnaire. Results: PPROM occurred in 44.7% of controls and 31.8% of cases. PROM occurred in 34.1% of controls and 18.8% of cases and mean gestational age at delivery (week) in control group 35.9 ± 2.8 and in the case group 37.1 ± 1.9. Rupture of membranes was significantly decreased in the case group.
Authors and Affiliations
Dr. Jannatul Ferdous, Dr. Mohammad Mostafizur Rahman, Babry Fatema
Keywords
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- EP ID EP238806
- DOI 10.9790/0853-1611067073
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