Subscription Page
Journal Title: Neuro-Oncology - Year 2010, Vol 12, Issue 5
Abstract
Authors and Affiliations
Keywords
Related Articles
- EP ID EP679612
- DOI 10.1093/neuonc/noq038
- Views 35
- Downloads 0
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
Glioblastoma (GBM) is a high-grade central nervous system malignancy and despite aggressive treatment strategies, GBM patients have a median survival time of just 1 year. Chloroquine (CQ), an antimalarial lysosomotropic...
Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial
The aim of this clinical trial was to investigate safety and efficacy when combining cetuximab with bevacizumab and irinotecan in patients with recurrent primary glioblastoma multiforme (GBM). Patients were included with...
Akt signaling pathway: a target for radiosensitizing human malignant glioma
Radiation therapy plays a central role in the treatment of glioblastoma, but it is not curative due to the high tumor radioresistance. Phosphatidyl-inositol 3-kinase/protein kinase B (Akt) and Janus kinase (JAK)/signal t...
Human umbilical cord blood stem cells show PDGF-D–dependent glioma cell tropism in vitro and in vivo
Despite advances in clinical therapies and technologies, the prognosis for patients with malignant glioma is poor. Neural stem cells (NSCs) have a chemotactic tropism toward glioma cells. The use of NSCs as carriers of t...
FasL gene knock-down therapy enhances the antiglioma immune response
Malignant glioma is a lethal form of brain cancer that is very difficult to treat. The aggressive behavior of these neoplasms and their limited responsiveness to therapy has been attributed in part to the ability of thes...