[sub][/sub]Role of Granulocyte Colony Stimulating Factor (G-Csf) in Neonatal Sepsis with Neutropenia
Journal Title: People's Journal of Scientific Research. - Year 2016, Vol 9, Issue 2
Abstract
Randomized controlled double blind trial was done at NICU, Department of Pediatrics, MLB Medical College, Jhansi to determine whether adjunctive therapy with G-CSF could reverse sepsis associated neonatal neutropenia and improve neonatal survival compared with conventional therapy. 52 neonates with sepsis and absolute neutrophil count(ANC)<1800/mm3. The G-CSF group (n=26) received G-CSF single daily dose of 10 mg/kg/day subcutaneously for 3 days along with conventional therapy while control group (n=26) received conventional therapy (antibiotic and supportive care) alone. Hematological parameters [ANC, total leukocyte count (TLC)] on day 0,1,3,7 & 14 of study entry, neonatal survival and duration of hospital stay were compared between two groups. Basic demographic profile among two groups were comparable. By day 3, ANC among G-CSF group was significantly higher 8292±605.21 compared to control group 1544.04±250.49(p value <0.0001). Mortality rate was significantly lower in G-CSF group than in control group 11.53% vs 46.15%. Duration of hospital stay in G-CSF group was 18.32±4.42 compared to 24.57±9.06 in control group( p value 0.0027). G-CSF can increase the neutrophil count, decrease mortality rate and reduce duration of hospital stay in critically ill septic neutropenic neonates. Further studies are required to confirm our results and establish the adjunctive therapy in neonatal sepsis
Authors and Affiliations
Priyanka Gupta, , RS Sethi,, Om Chaurasia, , Anuj Sethi,
Keywords
Related Articles
- EP ID EP123383
- DOI -
- Views 99
- Downloads 0
Sudden Visual Loss in a Diabetic Patient
We report a case of sudden monocular visual loss with drooping of upper eyelid in a 65 year old diabetic patient. Examination revealed complete ophthalmoplegia with optic neuropathy and paranasal sinusitis. Early diagno...
A study of Correlation of Transverse Cerebellar Diameter with Gestational Age in the Normal & Growth Restricted Fetuses in Western Uttar Pradesh
Transverse Cerebellar Diameter (TCD) is a more accurate & better predictor of gestational age in normal as well as in IUGR fetuses. In intra uterine growth restricted (IUGR) Fetuses, the transverse cerebellar diamete...
Bladder Exstrophy
Bladder exstrophy, more properly, the exstrophy-epispadias complex is a rare congenital anomaly occurring once every 10,000-50,000 live births with a 2.3:1 as male & female ratio. The diagnosis involves a spectrum of...
Endodontic Applications Of Spiral Computed Tomography Padma Nathani, Suresh Naik, M.P. Singh, Sharno Verghese
The variations in root canal morphology especially in multi-rooted teeth are a constant challenge for diagnosis and endodontic therapy. Complete knowledge of the root canal anatomy is mandatory because the non-treatment...
Compressive and Glaucomatous Optic Neuropathy: A Comparative Study
This research was aimed to study the etiology of optic atrophy and comparison of optic disc morphology between compressive and glaucomatous optic atrophy. It included 72 cases of optic atrophy admitted in Maharani Laxmi...