Successful Rapid Desensitization of Two Teenagers with Rituximab Hypersensitivity
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 5
Abstract
ABSTRACT Rituximab is one of the monoclonal antibodies that is used in the management of malignancies and auto-inflammatory disorders. Rituximab causes Hypersensitivity Reactions (HSRs) during infusions. The delay of treatment or loss of a highly efficient drug can be prevented by rapid drug desensitization method in patients who are allergic to rituximab. Although HSRs and desensitization protocols to mAbs have been well described in adults, the experience in the paediatric population is very limited. To best of author’s knowledge, this is the first case series describing a novel, rapid desensitization protocol against rituximab hypersensitivity in two teenagers with high-grade B cell non-Hodgkin’s lymphoma and steroid-resistant minimal change disease who developed hypersensitivity to rituximab. Here, authors present case reports of two patients who were desensitized successfully by using novel rapid desensitization protocol for rituximab.
Authors and Affiliations
Murat Cansever, Alper Ozcan, Ismail Dursun, Ekrem Unal, Fulya Tahan
Growth Charts for Egyptian Children with Achondroplasia
Abstract Introduction: Achondroplasia (ACH) is a dominant autosomal genetic disorder. The patients present with disproportionate short stature with short limbs and normal size torso due to abnormal bone growth. Growth ch...
Jigsaw Classroom: Is it an Effective Method of Teaching and Learning? Student’s Opinions and Experience
ABSTRACT Introduction: In this digital era with information overload it is important to train the students in a systematic approach to the information available and a positive interdependence for effective learning. Jigs...
Comparison of Polymerase Chain Reaction and Immunohistochemistry Assays for Analysing Human Papillomavirus Infection in Oral Squamous Cell Carcinoma
Introduction: Polymerase Chain Reaction (PCR) and Immunohistochemistry (IHC) are two well-known techniques used for the diagnoses of genetic diseases, tumours and different pathogens. PCR basically amplify regions of DNA...
Association of Metabolic Syndrome in Chronic Plaque Psoriasis Patients and their Correlation with Disease Severity, Duration and Age: A Case Control Study from Western Maharashtra
Introduction: Psoriasis is a chronic systemic inflammatory disease where the skin and the joints are the primary targets. Despite the fact that psoriasis carries minimal risk of mortality, it is associated with significa...
Insidious Role of Diabetes Mellitus on Nerves and Dental Pulp
ABSTRACT Diabetes Mellitus is a metabolic disorder with deleterious effect on the physiological functioning of body systems. The predisposition of body organs and tissues to infections, nervous and circulatory dysfunctio...