SUCCESSFUL TREATMENT OF INVAZIVE MUCORMYCOSIS FOLLOWING CHEMOTHERAPY IN A PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA
Journal Title: World Journal of Advance Healthcare Research - Year 2018, Vol 2, Issue 4
Abstract
Mucormycosis is a fungal infection mainly affects immunocompromised patients especially with malignant hematologic diseases. Fludarabine is commonly used chemotherapeutic agent in Chronic Lymhocytic Leukemia (CLL) which causes severe immunosupression and has been suggested to increase risk of invasive fungal infections. A 70-year old man with CLL developed severe mucormycosis after the first cycle of Fludarabine-Cyclophosphamide chemotherapy. He was treated successfully with extensive surgical debridement and intravenous liposomal Amphotericin-B. This case highlighted that fludarabinebased regimens can cause severe immunosuppression and fungal infections even after first cycle of chemotherapy.
Authors and Affiliations
Dr. Abdulkerim Yıldız
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