Sunitinib Induced Hypocalcemia and its Potential Role in the Treatment of Refractory Hypercalcemia
Journal Title: Open Access Journal of Endocrinology - Year 2017, Vol 1, Issue 1
Abstract
Background: Sunitinib, an oral multi-targeted tyrosine kinase inhibitor has been approved for the treatment of advanced pancreatic neuroendocrine neoplasms (pNENs). Aim: To describe a series of 12 patients with pNENs on sunitinib who developed hypocalcemia. Patients and Methods: Three patients developed hypocalcemia, grade 4, 1 and 2 respectively. Results: A 58-year-old man with a stage IV, grade 2, initially non-functioning pNEN (NFpNEN), developed disease progression with concomitant hypersecretion of parathyroid hormone related-peptide (PTHrP) and uncontrolled hypercalcemia. After one month of sunitinib treatment, grade 4 hypocalcemia (<6mg/dl) developed. Following treatment reinstitution at a lower dose, hypercalcemia became easily controlled. Another two patients with NFpNEN treated with sunitinib developed a grade 1 (8.2mg/dl) non-symptomatic and a grade 2 (7.2mg/dl) symptomatic hypocalcemia, both nine months after sunitinib was initiated. Conclusions: Sunitinib-induced hypocalcemia may be a common side-effect that could be of therapeutic significance in patients with pNEN and refractory PTHrP-related hypercalcemia.
Authors and Affiliations
Krystallenia I Alexandraki
Keywords
Related Articles
- EP ID EP448448
- DOI 10.23880/oaje-16000105
- Views 119
- Downloads 0
Unusual Association of Two Germline Rearrangements in CDC73/HRPT2 Gene: Complexity of Clinical Counseling in the Age of Genomic Medicine
Background: Primary hyperparathyroidism is a phenotype shared by several hereditary endocrine and non-endocrine cancer predisposition syndromes caused by heterozygous germline mutations deactivating tumor suppressor gene...
HbA1c-Glycated Hemoglobin: Perfect Tool to Curb the Diabetes
Bernard Baruch has very well said this quote as these questions are the basis of science and knowledge. Medical science is not different from it too. In routine day to day practice of medicine we come across with lot man...
Unexplained Hoarseness of Voice after Radioactive Iodine Therapy; A Rare Complication
Hoarseness of voice is extremely rare after radioactive iodine therapy for Graves’s disease. Here we report a case of 29 year old lady who received one dose of 15mCi of RAI. After one day she presented with severe hoarse...
Is there an Escalation of Type 2 Diabetes Mellitus in Children and Adolescents: Therapeutics and Preventive Approach
There is an increasing prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents from all over the world from various ethnicities, although the incidence of obesity is not increasing any more. Most of the...
Lymphadenopathy in Autoimmune Thyroiditis: Paratracheal Lymph Nodes are Indeed Crucial
Cervical lymphadenopathy is common in patients with autoimmune thyroiditis and supposed to be pathognomic for the disease if found in the paratracheal compartment (Robbins level VI). The aim of this prospective study is...