Survivin Immunoreactivity in the Gastric Mucosa of Rats Feedind with Carpet Shell Clam (Ruditapes decussatus)
Journal Title: Invention Journal of Research Technology in Engineering & Management - Year 2018, Vol 2, Issue 8
Abstract
Survivin has been studied many times because of its overexpression in several types of cancer including lung, kidney, skin, endometrium, stomach, colon, breast, prostate, over, hematologic, head and neck cancers, histopathology features and polymorphisms in the promoter region which belongs to the inhibitör of apoptosis gene family by researchers. There is no study of survivin immunoreactivity in the gastric mucosa of the rats fed with carpet shell clam grown in the Dardanelles. In this study, it was aimed to investigate the effects of carpet shell clam fed rats on survivin production in the gastric mucosa. The carpet shell clam given as food to the rats were removed from the Dardanelles Çardak region. Four groups of rats are included in the study, group 1 (n=6), control group fed with standard rat food, group 2 (n=6), 75% carpet shell clam and 25% standard rat food daily, group 3 (n=6), 75% carpet shell clam and 25% standard rat food every two days, group 4 (n=6), 75% carpet shell clam and 25% standard rat food every three days. To detect survivin localization in the tissues, the LAB-SA Detection System was used. Survivin immunoreactivity was detected of epithelial cells in the gastric mucosa of rats fed with carpet shell clam. After the immunohistochemical staining processing all gastric tissue samples are evaluated in terms of survivin immunoreactivity with light microscopy and image analysis software. Survivin immunoreactivity was detected 0% in the first group, 83.33% in the second group, 61.83% in the third group and 32.67% in the fourth group. There was statistically significant difference between the survivin immunoreactivity in the gastric gland cells of the rats in the experimental and control groups (p> 0.05). Survivin production in the gastric mucosa of rats suggests that consumption of carpet shell clam may cause tissue damage.
Authors and Affiliations
Aslı Muratlı
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