Susceptibility to antifungal drugs of Candida albicans isolated from upper respiratory tract of patients with chronic hepatitis C
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2013, Vol 7, Issue 2
Abstract
Introduction. Patients with chronic HCV infection due to itheir mmunocompromised status are predisposed to opportunistic infections caused by microorganisms of normal microflora, e.g. fungal infections caused especially by yeast species belonging to Candida spp., mainly Candida albicans.Objective. The aim of this study was to analyze the drug susceptibility of Candida albicans colonizing the pper respiratory tract isolated from 100 patients with chronic hepatitis C from group I (without antiviral herapy) and from group II (treated with peginterferon and ribavirin).Material and Methods. The 30 isolates of C. albicans from group I and 31 isolates from group II were identified by standard methods – biochemical microtest API 20 C AUX (bioMérieux). The drug sensitivity to antifungal drugs (amphotericin B, flucytosine, fluconazole, itraconazole, ketoconazole and miconazole) was estimated by the Fungitest method (Sanofi Diagnostics Pasteur).Results. Among the isolates of C. albicans, 100% sensitivity to flucytosine and amphotericin B was found, irrespective of the patient group. However, a decreased sensitivity to azole derivates – miconazole, ketoconazole, itraconazole or fluconazole – was noted, amounting to 3.33 – 56.67% in the isolates from group I, while in group II amounting 9.68 – 48.39%, depending on the antifungal drugs. The isolates esistant to ketoconazole (6.67%) or itraconazole (10%) were found in group I, while resistant to miconazole (9.68%), ketoconazole (19.35%), itraconazole (22.58%) or fluconazole (3.22%) in group II.Conclusion. Determination of drug sensitivity of the isolated yeast species should be the basis of rational and successful therapy.
Authors and Affiliations
Anna Biernasiuk, Sławomir Kiciak, Krzysztof Tomasiewicz
Keywords
Related Articles
- EP ID EP58793
- DOI -
- Views 179
- Downloads 0
The assessment of selected factors influencing intent to get pregnant in the Greater Poland Region
introduction and objective. Nowadays, people decide to have a baby by first analysing their financial situation. Tradition is no longer a factor which determines the decision whether or not to have a baby. A prognosis of...
Dietary habits and body image perception among Polish adolescents and young adults - a population based study
Patterns of nutritional behaviours shaped in childhood and during the period of adolescents are mostly continued in adult life, and on these patterns, to a great degree, depends the risk of development of many chronic di...
Should a doctor stop rendering medical services? Part II – Analysis of medico-legal conduct in cases of uncertainties regarding informed consent in minors. The Polish perspective
introduction. The doctor’s decision whether to save the life of a minor who has attempted to commit suicide depends on the decision of the person who, under legal regulations, is responsible for the minor. In everyday me...
Brucellosis in humans – etiology, diagnostics, clinical forms
Brucellosis in humans is a zoonosis of greatly varied clinical image. It occurs on all inhabited continents. The course of the disease may be acute, sub-acute or chronic. The etiologic factors of brucellosis are small,...
Psychosocial factors and health-related behavior among students from South-East Poland.
The aim of this study was to determine the meaning of selected social-demographic factors, such as: gender, place of resident, education, level of knowledge about health and life orientation in modifying the behaviours r...