SYNERGISTIC ANTI-INFLAMMATORY INTERACTION BETWEEN VITAMIN B12 AND KETOROLAC IN THE PAW EDEMA TEST
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2016, Vol 1, Issue 1
Abstract
Background: Vitamin B12 have been used for long, either alone or with or without other analgesics for treatment of different painful and inammatory conditions. However, comparison of these effects with similar effects of ketorolac tromethamine (KT) and their combination have not been established. Objective: To assess the effects of vitamin B12 on inammation and also to compare them with those of the combinations of vitamin B12 with KT in rat models. Methods: This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2015 to February 2016. For this, 20 (twenty) Long Evans rats (215±35 gm) of either sexes were divided into control (A, with 5 ml/kg normal saline) and experimental (B1, with 15 mg/kg vit.B12; B2, with 10 mg/kg KT; B3, with B12+KT) groups with 5 rats in each group. All the drugs and vitamin were administered intraperitoneally in a single dose just two hours before paw edema test. To evaluate the treatments' effect on inammation, paw edema volume in the paw edema test were observed after administration of subcutaneous formalin (50 μl, 2.5%) injection into the plantar aspect of the right hind paw. Statistical analysis was done by ANOVA, followed by Bonferroni post hoc test. In the interpretation of results, p≤0.05 was considered as signicant. Results: KT lowered edema volume signicantly (p≤0.01) in the paw edema test. On the other hand, combination of B12 and KT signicantly (p≤0.001) lowered the edema volume in the paw edema test. Conclusion: From this study it may be concluded that, vitamin B12 possess anti-inammatory effects and combination of B12 with KT is more effective than those of their individual administration.
Authors and Affiliations
Mizanur Rahman, Noorzahan Begum, Taskina Ali, Mahadi Abdur Rouf, Shahriar Masood
Keywords
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