Syntezy układu tiazolo[4,5-d]pirymidyny
Journal Title: Wiadomości Chemiczne - Year 2014, Vol 68, Issue 1
Abstract
This review is focused on the literature data about the preparation of the thiazolo[4,5-d]pyrimidine scaffold. The synthesis of this ring system has been accomplished by various methods. The synthesis can proceed via a pyrimidine onto which a thiazole ring can be annulated. The second approach involve annulation of a pyrimidine ring onto the preformed thiazole ring. Thiazolo[4,5-d]pyrimidines have been obtained by condensation of pyrimidine derivatives with thioamides [2], thionyl chloride [3], thiourea [4], bromomalononitrile [5], isothiocyanates [6] or under the influence of temperature [7]. However, most of the literature refers the methods of synthesis which begin with formation of the appropriately substituted thiazole ring. This synthetic route for preparation of fused derivatives utilizes orhtoesters [8, 9], acetic anhydride [9,10], formic acid derivatives [11, 12], carbon disulfide [13,14], appropriate isothiocyanates [15-18], urea and hydrazine derivatives [19–23], aromatic aldehydes and acid chlorides [24, 25] as key building blocks. Cyclization also occurs in high temperature or acidic reaction medium [26, 27]. The solid-phase synthesis was also described [28].
Authors and Affiliations
Lilianna Becan
Immobilizowane alfa-amylazy i celulazy w zastosowaniach praktycznych
Today, more and more products made in biotechnological processes involving enzymes. The stability of the enzyme under process conditions are subjected to the immobilization on solid supports, which leads to a heterogeneo...
Różność czy identyczność Vestium /Rutenu?
Brak
Zastosowanie spektroskopii w podczerwieni w adsorpcji i katalizie (II)
The review presents important results on infrared examination of adsorbents and catalysts, which were obtained in Laboratory of Adsorption and Catalysis in Environmental Protection at Adam Mickiewicz University – conduct...
Prolina : pospolity aminokwas wyjątkowy katalizator. Część III, Reakcja Mannicha
Mannich reaction occuring among ketone, aldehyde, and amine is one of the ways of a synthesis of biologically active compounds. Reactions of this type were carried out in the presence of different catalysts [3–10], howev...
Okruchy XXV. O kreatywnym autyzmie
brak