Syntheses, Characterization and Antimicrobial screening of some Novel Benzimidazoles
Journal Title: Hygeia:journal for drugs and medicines - Year 2015, Vol 7, Issue 1
Abstract
Plan: Present work aims to synthesize a series of new benimidazoles (SBS-a-m) with various substitutions at 2-o-amino phenyl position and to evaluate their in-vitro antibacterial and anti-fungal activity. Prologue: Benzimidazole containing organic compounds forms a significant group of drugs which exhibit an array of biological activities ranging from antibacterial, antifungal, anti-inflammatory, analgesic, anthelmintic activities and so on. Methodology: The starting material SBS was synthesized by microwave irradiation of o-phenylenediamine and anthranilic acid mixture in presence of polyphosphoric acid. SBS was further derivatized to Schiff bases (SBS-a-m) by reacting with various substituted aromatic aldehydes. The in-vitro antibacterial and anti-fungal activity was carried out by the agar diffusion method using Ampicillin and Miconazole nitrate respectively as standards at a concentration of 50µg/0.1ml. Outcome: SBS-k was found to be most active on all the bacteria used and SBS-e showed good activity against both Gram-positive bacteria and moderate activity against both Gram-negative bacteria. No compound showed significant antifungal activity.
Authors and Affiliations
Satyendra Deka, Bandita Sarma, Shamanna Mohan, JanardhanSaravanan
Keywords
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- EP ID EP401489
- DOI 10.15254/H.J.D.Med.7.2015.141
- Views 51
- Downloads 0
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