SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SCHIFF BASE DERIVATIVES OF 4-CHLORO-3-NITROBENZOIC ACID
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
4-chloro-3-nitrobenzoic acid was selected as nucleus structure having good antibacterial property. It was thought worthwhile to synthesize Schiff base derivatives of 4-chloro-3-nitrobenzoic acid in search of better antibacterial agents. The compounds were synthesized by first reducing nitro group in presence of Sn/HCl to 3-amino-4-chlorobenzoic acid, which on treatment with substituted benzaldehyde afforded the synthesis of the envisaged compounds. The synthesized compounds were purified and chemically characterized. They were screened for their antibacterial activity and result suggested that SKY-1, SKY-5 and SKY-8 were highly active against both Gram (+) and Gram(-) bacteria like B.subtilis, S.aureus and E.coli whereas all are were found moderately to inactive against P.aeruginosa.
Authors and Affiliations
Santosh Kumari , Dharmchand Singh
Keywords
Related Articles
- EP ID EP103738
- DOI -
- Views 94
- Downloads 0
PROTECTIVE EFFECT OF LORANTHUS LONGIFLORUS ON LEARNING AND MEMORY OF RATS EXPOSED TO ELECTROMAGNETIC RADIATION (EMR)
The interaction of mobile phone radio-frequency electromagnetic radiation (RF-EMR) with the brain is a serious concern of our society. In this study, we aimed to experiment on the antioxidative property of a parasitic pl...
BIOLOGICAL AND ANTIOXIDANT ACTIVITIES OF SILENE SP.
Silene L. is one of the most recognized and widespread genus of Caryophyllaceae family, with more than 700 species on the earth. It is originated from the Mediterranean Region, and this genus is spread out in mild climat...
ANALYSIS OF PHYTOCHEMICAL COMPOSITION AND BACTERIOSTATIC ACTIVITY OF TAGETES SP
Present study was carried out to investigate the antimicrobial effect of ethanolic extracts of leaves and flowers of Tagetes erecta Linn and Tagetes patula Linn. After performing preliminary phytochemical screening and...
SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND NIACIN IN TABLET DOSAGE FORM
Two UV spectrophotometric methods were developed and validated for quantitative determination of atorvastatin (ATR) and niacin (NIA) in tablet dosage form. Method I is based on the simultaneous equation, and method II is...
KNOWLEDGE, ATTITUDE AND PERCEPTION TOWARDS JAUNDICE AMONG AYDER REFERAL HOSPITAL HEALTH WORKERS
The objective of the study was to determine knowledge, practice and attitude towards jaundice among hospital health workers in Ayder Referral Hospital. Jaundice is a condition in which a person's skin and the whites of t...