Synthesis and Anticancer Activity of Some New Stilbene Derivatives
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 12
Abstract
The present study was aimed to synthesize derivatives of cisstilbene and evaluate for their anti-cancer activities. Several cisstilbenes with substitutions on the olefinic carbon were synthesized and characterized by IR, NMR, and MASS spectra. Some compounds from each series were evaluated for their cytotoxicity against MCF-7 and HeLa cell lines. Among all the compounds, compound 4c with methyl ester group on olefinic carbon exhibited potent activity against MCF-7 and HeLa cell lines with IC50 values 22.24µM and 27.43µM respectively. Keywords:stilbene, olefine, cytotoxicity.
Authors and Affiliations
Rathnakar Reddy Kotha, Anil Kumar Garige, Achaiah Garlapati
Keywords
Related Articles
- EP ID EP378403
- DOI -
- Views 95
- Downloads 0
Synthesis, characterization and Evaluation for Antidepressant activities of some Novel 4-Thiazolidinone Derivatives
4-thiazolidinone and their derivatives were possessed a wide range of pharmacological activities such as antiinflamatory , analgesic, anticonvulsant, antimicrobial (antibacterial and antifungal), local and spinal anaesth...
Effect of Preservative in the Physicochemical Stability of Cosmetic Products Based on Natural Resources from Costa Rican Flora
A problem of rural women in Latin America is the poor access to economic resources; a solution we propose is to implement a collaborative model, where are used natural resources in the area for production of value added...
The Effect of Feeding Commercial Oil of Black Cumin in Sheep
This study investigated the effects of feeding commercial oil of the Black cumin (seeds of Nigella sativa) on the levels of total cholesterol and the body weights in sheep. Twelve male cross breed sheep were divided indi...
Deleterious effects of smoking in male patients in a tertiary care hospital
Abstract:This study explains the deleterious effects of cigarette smoking in patients of SSSMC&RI, Ammapettai. In this study we have collected a history of 75 patients in SSSMC&RI. This history has been collected based o...
Formulation and Characterization of Tramadol Emulgel
Topical drug delivery system (TDDS) facilitates the passage of therapeutic quantities of drug substance through the skin and into the general circulation for their systemic effects. Although having plenty of advantages o...