SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 2-NAPHTHYLACETATE MANNICH BASES
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 6
Abstract
Using 2-naphthylacetate as active hydrogen component, the following Mannich bases were synthesized via a general synthesis protocol: 1-hydroxymethyl-1-piperidinomethyl-2-naphthylacetate(I); 1,1-dimorpholinomethyl-2- Naphthylacetate(II) and 1,1-bis-dimethylaminomethyl-2-naphthylacetate(III).The structures of the final products was elucidated by a combination of spectral techniques (UV,IR , 1HNMR and MS). The target molecules were evaluated for antimicrobial activity against six standard human pathogens. Significant activity was exhibited by compound I. It showed antimicrobial activity against all test organisms. Compounds II and III showed significant antifungal activity,
Authors and Affiliations
Prof. Abdel Karim M.
Keywords
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