Synthesis and antimicrobial evaluation of N-(2-(4-chlorophenyl)-4-oxothiazolidin-3-yl benzamide derivatives
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 1
Abstract
Thiazole is five membered ring system with one nitrogen and one sulphur atom. Some thiazole derivatives were synthesized and confirmed their antimicrobial activity. Many researchers reported about thiazole & their derivatives as antimicrobial, anticancer, antidiabetic, diuretics, antidepressant, anticonvulsant, anti-HIV anti-inflammatory and anti-tubercular. N-(2-(4-chlorophenyl)-4-oxothiazolidin-3-yl benzamide derivatives were synthesized with the help of benzoyl chloride and hydrazine to synthesize substituted benzohydrazides followed by synthesis of N-(4-chloro benzylidene) aryl hydrazide. Antimicrobial activity was performed against gram positive species Bacillus subtilis, S. pyogenes and gram negative species Pseudomonas aeruginosa, Escherichia coli and for antifungal Candida albicans, Aspergillus niger species were used. In synthesized thiazole derivatives those derivatives have good antimicrobial activity in which phenyl ring was substituted with electron donating groups like hydroxyl, amino, methoxy. Hydroxy and amino substituted derivatives have maximum antimicrobial activity. Trimethoxy substituted derivatives have good activity than dimethoxy and monomethoxy substituted derivatives. Electron withdrawing moieties have very low activity like nitro substituted compounds.
Authors and Affiliations
Amit Chawla*| Research Scholar, Punjab Technical University, Kapurthala, Punjab, India.-Khalsa college of Pharmacy, Amritsar-143 001, Punjab, india., Payal Chawla| Research Scholar, Punjab Technical University, Kapurthala, Punjab, India.-Khalsa college of Pharmacy, Amritsar-143 001, Punjab, india., Uttam Singh Baghel| Khalsa college of Pharmacy, Amritsar-143 001, Punjab, india.
Keywords
Related Articles
- EP ID EP2387
- DOI -
- Views 406
- Downloads 25
OCCURRENCE OF MALIGNANT TUMORS OF PARANASAL SINUSES IN KARNATAKA
Introduction: malignancy of paranasal sinuses is wide spread. Paranasal sinuses are in close anatomical relationship with skull viscera. Clinical assessment get hampered by surrounding bony structures, diagnostic radiolo...
DETECTION OF EPSTEIN - BARR VIRUS IN LYMPHOMA LESIONS AMONG SUDANESE PATIENTS USING LMP-1 MONOCLONAL ANTIBODY
OBJECTIVE: this was a retrospective descriptive study aimed to investigate the association of EBV with different types of lymphoma in Sudanese patients. METHODS: Fifty paraffin-embedded formalin-fixed tissue sections of...
OPTIMIZATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) OF REPAGLINIDE USING D-OPTIMAL MIXTURE EXPERIMENTAL DESIGN
Repaglinide, which is widely used in treatment of type 2 diabetes, is practically insoluble in water with low bioavailability (about 50%) and poor absorption characteristics in upper intestinal tract. Self-nanoemulsifyi...
MOLECULAR TARGETS USED IN VALIDATION AND CORRECTIONS IN ARTIFACTS OF PCR BASED INFECTIOUS AGENTS DIAGNOSIS
With the advents of Nucleic Acid amplification Technologies (NAAT), utilized for the molecular diagnosis of infectious agents, it become very significant for the validation of the protocols. Present review focuses on th...
CHROMATOGRAPHIC FINGERPRINT ANALYSIS OF FLAVONOIDS OF ACHYRANTHES ASPERA LINN. BY HPTLC
The study was carried out with an aim to determine the chemical profile and flavanoid composition of the medicinally important plant Achyranthes aspera Linn. from methanolic extract of root, stem and leaf. Preliminary ph...