Synthesis and Bio-Spectral Studies of Co(II) Complex of 5-Chloro-2,4-Dihydroxy Butyrophenoneoxime (CDHBOX)
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 6, Issue 3
Abstract
Co(II) complex of 5-chloro-2,4-dihydroxy butyrophenoneoxime (CDHBOX) was synthesized from 5-chloro-2,4-dihydroxy butyrophenoneoxime by using standard protocol, and characterized by elemental analyses, melting point determination and spectral data. The ML2 (metal/ligand) stoichiometry of the complex was determined by spectrophotometric and potentiometric studies, and mass spectral data. The value of stability constant of the complex was found to be 6.94x 108 while its standard free energy of formation is 12.155 kcal/mol at 27ºC. Beer’s law is obeyed in the concentration range 2-15 ppm of Co. The value of molar extinction coefficient and sensitivity as per Sandell’s scale were found to 3.35x 103 L.mol-1cm-1and 0.017 μg Co/cm2 respectively. The value of activation energy and the Arrhenius constant Arrhenius constant were found as 4.949 kjmol-1, 74.39. The IR studies reveal that the phenolic proton is lost on complexation and the oxygen of the phenolic (–OH) and nitrogen of the oximino (=NOH) groups coordinate with Co(II) ion. The electronic spectra and magnetic susceptibility measurement indicate that the complex is paramagnetic and tetrahedral in nature. The antimicrobial activity of different concentrations of ligand and its Co(II)-complex  has been evaluated against Curvularia lunata, Fusarium oxysporum and Alternaria alternata fungi  and Streproproteus, Staph, Escherchia coli, Klebsella, and pseudomonas bacteria. The results indicated that the ligand (CDHBOX) and its Co(II) complex have good anti-microbial properties.Â
Authors and Affiliations
F. Rehman, M. Bhardwaj, U. K. Jetley
Keywords
Related Articles
- EP ID EP652625
- DOI 10.24297/jac.v6i3.2650
- Views 172
- Downloads 0
Enhanced Antimicrobial activities of Hybrid ZnMgAlO nanocomposite by soft chemical method
In the present investigation, ZnMgAlO nanoparticles were prepared by soft chemical method. The synthesized NPs were analyzed by XRD and SEM EDAX. ZnMgAlO crystal structure was confirmed through powder XRD technique as...
Utility of Certain Nucleophilic Aromatic Substitution Reactions for the Assay of Ethamsylate in its Dosage forms and in Presence of its Degradation Product
The study represents the first report on the development of spectrophotometric methods for determination of ethamsylate (EST) in the presence of hydroquinone as an impurity and/or acidic degradation product. The proposed...
Myths and verities in protein folding theories Part II: From Kauzmann’s conjecture to the dominance of the hydrophobic effect
   We start with Kauzmann’s conjecture regarding the factor which is most likely to determine the stability of the 3D structure of the proteins. We show first that Kauzmann’s model-process, on which the original...
Synthesis and Antimicrobial Activity of some Novel Isoindoline-1,3-Dione Derivatives
New phthalimido derivatives incorporated with chalcone, pyrazole, pyrazoline, and pyrimidine moieties were synthesized and evaluated for their antimicrobial activities against bacterial and fungal strains. 2-{4-[1-Acet...
Green synthesis of Novel Schiff bases derived from 2, 6 diamino pyridine – Characterization and Biological activity
Present work produces an excellent green route for the synthesis of Schiff bases derived from 2, 6 diamino pyridine, by using lemon juice as the catalyst. This method is experimentally simple, quick, clean and high yield...