SYNTHESIS AND BIOLOGICAL ACTIVITY OF DERIVATIVES (2-METHYL (PHENYL) -6-R-QUINOLIN-4-YL-SULPHANYL) CARBOXYLIC ACIDS
Journal Title: Science Review - Year 2017, Vol 7, Issue 7
Abstract
Selection of potential bioactive molecules (2-methyl (phenyl) -6-R-quinolin-4-yl-sulfanyl) carboxylic acids and their derivatives with virtual screening (PASS-prognosis) and QSAR analysis was carried out. The most promising compounds were synthesized and their toxic effects were studied. They found themselves as little or moderately toxic biologically active substances. The conducted experiments indicate the expediency of in-depth study of derivatives (2-methyl (phenyl) -6-R-quinolin-4-yl-sulfanyl) carboxylic acids as potential bioregulators.
Authors and Affiliations
O. A. Brazhko, M. P. Zavgorodniy, A. V. Lagron, M. M. Kornet, I. V. Dobrodub
Keywords
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