SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 2, 4, 5 TRIPHENYL IMIDAZOLE DERIVATIVES
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
A series of 1-substituted 2, 4, 5 triphenyl imidazoles were synthesized by the reaction equimolar mixture of 2, 4, 5 triphenyl imidazole with chloro compound in the presence of anhydrous potassium carbonate. The newly synthesized compounds were characterized on the basis of UV, IR and H1 NMR spectra. The synthesized compounds were screened for antiinflammatory, antimicrobial activities. Antiinflammatory activity was screened by carageenan induced rat paw oedema method. Compounds T4 & T5 showed highly significant activity. Antimicrobial activity was screened by disc-plate method. All the compounds showed mild to moderate activities.
Authors and Affiliations
A. Yasodha , A. Sivakumar , G. Arunachalam , A. Puratchikody
Keywords
Related Articles
- EP ID EP149895
- DOI -
- Views 144
- Downloads 0
Selection of better method for the preparation of microspheres by applying Analytic Hierarchy Process
One of the most effective approaches for achieving novel drug delivery dosage forms such as sustained release, controlled release is microencapsulation. A number of techniques are available for thepreparation...
New RP - HPLC Method for the Determination of Valproic acid in Human Plasma
A simple reverse phase HPLC method was developed for the determination of Valproic acid present in human plasma. A Denali, Grace, C18, 4.6 X 150mm, 5ยต in an isocratic mode with mobile phase containing 40mM Ammonium dihyd...
Hemlock poisoning due to plant misidentification
A case report (two patients) of accidental intoxication occurred in Northern Italy. Conium maculatum L. (poison hemlock) leaves were confused with and collected as Foeniculum vulgare Mill. (sweet fennel). C. m...
Physicochemical Characterization and Evaluation of Mucoadhesive Tablets of Omeprazole for Local Action
In the present work, we developed an effective mucoadhesive tablets of omeprazole(Diomeprazole magnesium powder and omeprazole pellets) by direct punch method with excellent mucoadhesive force using three...
Intellectual Property RLghts