SYNTHESIS AND CHARACTERIZATION OF 1, 3, 4-OXADIAZOLE AND 1,3,4- THIADIAZOLE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1, 3, 4-oxadiazole and 1,3,4- thiadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Literature is flooded with reports of a variety of biological activities of 2, 5-Disubstituted-1,3,4- oxadiazoles and 1,3,4- thiadiazole. The search for better anticonvulsant drug and the importance of 2,5- disubstituted 1,3,4-oxadiazoles and 1,3,4- thiadiazole as anticonvulsant pharmacophores, prompted us to design, synthesize and evaluate a series of differently substituted 1,3,4-oxadiazoles and 1,3,4- thiadiazole for their potential anticonvulsant activity by autodock software.
Authors and Affiliations
Ramanji Naik
Keywords
Related Articles
- EP ID EP33062
- DOI -
- Views 305
- Downloads 0
EVALUATION OF ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF FLOWERS OF CASSIA SIAMEA IN ALLOXAN INDUCED DIABETIC RATS OF BASAL DIET AND MAIDA MIXED DIET
This study was carried out to evaluate the antihyperglycemic effect of the Methanol extracts of the flowers of C. siamea on alloxan induced rats of normal diet and maida mixed diet. The extracts were orally administered...
A simple validated UV spectrophotometric method for quantitative analysis of Levetiracetam in pharmaceutical dosage form
In the present study simple, precise, accurate, economical and reliable UV spectrophotometric method has been developed for the estimation of Levetiracetam in tablet dosage form. The drug shows maximum absorption (maxi...
Formulation and evaluation of matrix floating tablets of Norfloxacin and Tinidazole combination
Floating drug delivery systems have shown to be of better significance in controlling release rate for drugs having site specific absorption. The present study was an attempt to develop floating tablets Tinidazole and...
Conservative management of allergic respiratory illness in the light of Ayurveda & Plant Biotechnology: A literary review
The term Allergy refers to expression of an ‘altered state of reactivity’ to common environmental antigens. Allergic diseases have a familial predisposition and common target organs are lungs, nose and skin. Common all...
DEVELOPMENT AND EVALUATION OF HIGH POROUS MOUTH DISSOLVING TABLETS CONTAINING LAMOTRIGINE COMPLEXATION
Lamotrigine (LMG) is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.17...