Synthesis and characterization of copper-loaded hydroxyapatite-alginate microspheres
Journal Title: Хімія, фізика та технологія поверхні - Year 2017, Vol 8, Issue 4
Abstract
Microspheres of hydroxyapatite (HA) in alginate (Alg) shell can be successfully used for controlled release of drugs, growth factors, and antibacterial compounds. Hydroxyapatite is a perfect material for biomaterials production due to its high sorption capacity to metal ions, low solubility in water, high stability to oxidisers and reducers, low cost and biocompatibility. Sodium alginate used for microspheres formation due to its cross-linking capability with divalent cations (Cu2+, Ca2+ etc.). Microspheres HA/Alg-Cu were obtained by 2 variants of synthesis and showed more rough surface than that of microspheres HA/Alg-Ca what is better for cell proliferation. XRD results show that HA is the main crystalline phase in obtained microspheres. According to the results of adsorption kinetics study, HA has the main contribution in process of Cu2+ ions adsorption. The temperature, increasing the rate of the adsorption process, has negligible effect on the adsorption capacity of HA due to the saturation of energetically heterogeneous active sites on the microspheres surface with Cu2+ ions. Adsorption index of HA/Alg microspheres to Cu2+ ions was calculated to be above 60 mg/g. Adsorption of Cu2+ ions on HA/Alg microspheres has an ion-exchange character. Due to the Cu2+ ions release obtained microspheres showed antibacterial effect on S. aureus and E. coli in concentration 6 mg/mL.
Authors and Affiliations
A. A. Yanovska, S. B. Bolshanina, A. S. Stanislavov, V. N. Kuznetsov, A. B. Mospan, V. Yu. Illiashenko, Yu. V. Rogulsky, Ya. V. Trofimenko, S. N. Danilchenko
Keywords
Related Articles
- EP ID EP252147
- DOI 10.15407/hftp08.04.400
- Views 107
- Downloads 0
Наночастицы гидрофосфата циркония, армированные слабокислотным катионообменным полимером
Слабокислотная катионообменная смола модифицирована наночастицами гидрофосфата циркония. Материалы исследованы методами эталонной контактной порометрии и трансмиссионной электронной микроскопии. В фазе полимера найдены к...
Properties of polyethylene–carbon nanotubes composites
The production of stable dispersions of carbon nanotubes (CNTs), synthesized by CVD, in different liquids, is one of the methods of preparation of CNTs for introduction into polymeric matrix. The aim of this work is to p...
Double-layer silicene-based carcerands: molecular containers for unstable compounds
We have studied the formation of a “host-guest” type сarcerand with a double-layer silicene (DL-S) as a host and an unstable antiaromatic cyclobutadiene as a guest. By employing the methods of MM+, РМ3 and Monte-Carlo,...
Композит, состоящий из гидратированного диоксида циркония и оксида графена, для извлечения органических и неорганических компонентов из воды
Цель работы заключалась в разработке многофункционального адсорбента, который способен удалять из водных растворов как неорганические ионы, так и молекулярные органические соединения. Окисленный графен получали по методу...
Relaxation of excess minority carrier distribution in macroporous silicon
Relaxation of the excess minority carrier distribution in macroporous silicon structure was calculated using the finite difference method. The initial distribution of the excess minority carriers has two maxima after car...