Synthesis and Characterization of Hydrazide-Hydrazone Derivatives of 3-Pyridine Carboxylic Acid as Antimycobac-Terial Tuberculosis Agents
Journal Title: Journal of Reports in Pharmaceutical Sciences - Year 2012, Vol 1, Issue 1
Abstract
In this study synthesis of nicotinoyl hydrazone derivatives is investigated by introducing the nicotinicacidhydrazidepharmacophore into several molecules and screening for antimycobacterial activity. Benzaldehyde derivatives react with nicotinicacidhydrazideto form nicotinoylhydrazones.The synthesized compounds were screened against M. tuberculosis H37Rv, clinical isolates of M. tuberculosis and MDR clinical isolates of M. tuberculosisusing the proportion test. The minimum inhibitory concentration (MIC) of N'-(4-methylphenyl) nicotinicacidhydrazone and N'-(4-(N,N-dimethyl)phenyl)nicotinicacidhydrazone exhibited activity between 40A and 200Aµg/mL and could be a good start point to find new lead compounds againstA M. tuberculosis.
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