SYNTHESIS AND EVALUATION OF ANTIANGIOGENIC AND ANTICANCER PROPERTIES OF NOVEL OXADIAZOLE ANALOGUES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 6
Abstract
Oxadiazole, a heterocyclic nucleus has attracted a wide attention of the chemist in search for the new therapeutic molecules. Out of its four possible isomers, 1, 3, 4-oxadiazole is biologically active, synthetically useful and widely exploited for various applications. Various biological activities are reported to be associated with 1, 3, 4-oxadiazoles. Encouraged by these reports the present study has been undertaken. The newly synthesized compounds were confirmed from IR, 1H NMR and mass spectral data. All the synthesized compounds were subjected for anti angiogenesis as well as anticancer activity. Compounds 7b and 10d showed very good anti angiogenesis and anticancer activity compared to all other analogues in the series.
Authors and Affiliations
Girish V, Rekha N. D, Lakshmi Ranganatha , Manjula S. N, Shaukath Khanum
Keywords
Related Articles
- EP ID EP116072
- DOI 10.7897/2230-8407.0506101
- Views 85
- Downloads 0
ETHNO BOTANICAL SURVEY OF PLANTS USED BY FOLKLORE PRACTITIONERS OF HAVERI DISTRICT, KARNATAKA, INDIA IN TREATING SEPTIC CONDITIONS WITH SPECIAL REFERENCE TO ACACIA FARNESIANA LINN AND PERGULARIA DAEMIA LINN AND THEIR ANTI BACTERIAL ACTIVITY
Ayurveda is time tested , treasured and archaistic science. 70% of India’s medicinal plants are found in the tropical zone. Mixed vegetation of both wet and dry landscape of Haveri district sources a variety of medicinal...
EFFECT OF THE PREPARATION OF SOLID DISPERSION METHOD ON THE SOLUBILITY AND CRYSTALLINITY OF SULFASALAZINE
The solubility, dissolution and physicochemical properties of the sulfasalazine in the three solid dispersions were evaluated compared to drug powder using Scanning electron microscopy, differential scanning colorimetric...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ATENOLOL AND CHLORTHALIDONE FROM PHARMACEUTICAL FORMULATION
A reverse phase high performance liquid chromatography (RP HPLC) method was developed and validated for the simultaneous estimation of atenolol and chlorthalidone in marketed formulation. The determination was carried ou...
EVALUATION OF ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF DALBERGIA SISSOO LEAVES IN EXPERIMENTAL ANIMALS
Gastric ulcer is one of the major health problems in developing countries. Furthermore, high cost and of adverse effects are seen with the long term use of allopathic drugs in treatment of ulcer which are diminished by t...
ANTICONVULSANT ACTIVITY OF MORINGA OLEIFERA LEAF
Moringa oleifera which is commonly known as drumstick tree has been used for its nutrition value and extensively used as a CNS depressant traditionally. Present work has been carried out to evaluate the anticonvulsant ac...