SYNTHESIS AND EVALUATION OF ANTIMICROBIAL PROPERTIES OF AZO DYES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: To synthesise and evaluate the antimicrobial potential of azo dyes in the quest of discovering lead molecules.Methods: A number of azo compounds have been synthesized via diazotization of the primary aromatic amine and subsequent coupling with naphthols or other coupling partners. The antimicrobial properties of these azo compounds were determined against six microbes; Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC10231), Mycobacterium smegmatis (clinical strain), Micrococcus luteus (ATCC10240), Pseudomonas aureginosa (ATCC 9027) and the fungi species Candida albicans (ATCC10231) using the Kirby-Bauer Standard disc diffusion method. The minimum inhibition concentrations were also determined for those that exhibited antimicrobial activity.Results: Two of the azo compounds showed antimicrobial potential with p-NAαN in particular exhibiting very good antimicrobial properties. However, Pseudomonas aureginosa (ATCC 9027) was resistant to all the azo compounds.Conclusion: During effective in-vitro control,p-NAαN showed broad spectrum of activity against Staphylococcus aureus, Escherichia coli, Mycobacterium smegmatis, Micrococcus luteu sand the fungi species Candida albicans, with p-ABAα Nexhibiting activity against Candida albicans.
Authors and Affiliations
William Kofie, Cedric Dzidzoramengor, Reimmel K Adosraku
Keywords
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