SYNTHESIS AND EVALUATION OF NOVEL THIAZOLIDINEDIONE DERIVATIVES FOR ANTIDIABETIC ACTIVITY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 5
Abstract
The aim of study was to synthesize a new series of thiazolidinedione’s. Thiazolidinedione’s or glitziness forms a significant class of drugs which exhibit biological activities ranging from antidiabetic, anti-inflammatory, antibacterial, antifungal, antiviral and anticancer. In the present study reported a systematic synthesis of thiazolidinedione analogues. A new series of 2, 4-thiazolidinedione based derivatives have been synthesized by the condensation of various substituted phenoxy benzene amines and 4’-chlorosulphonyl 5-benzylidene-2, 4-thiazolidinedione. The structure of these compounds were established by IR and 1H NMR. These new compounds (F1 – F7) were evaluated for their antidiabetic activity on albino rats. Most of the compounds showed significant antidiabetic activity when compared with the standard drug metformin.
Authors and Affiliations
Swapna D, Sivagami B, Manasa K, Rajita G , Alagarsamy V
Keywords
Related Articles
- EP ID EP123129
- DOI 10.7897/2230-8407.07544
- Views 95
- Downloads 0
DRY GRANULATION TECHNIQUE FOR CONVERTING TRIPHALA CHURNA AS GRANULES, TABLETS AND ORGANOLEPTIC EVALUATION
The objective of this research work was the conversion of Triphala churna into stable, palatable and patient acceptable granules to swallow conveniently by dry granulation methods, using suitable binding agents. The chur...
A NOVEL EXPLORING APPROACH OF CANCER CHEMOTHERAPY BY MULTIPLE EMULSION SYSTEM
Cancer is a disease characterized by uncontrolled multiplication and spread of abnormal forms of the body's own cells, leading cause of death worldwide, accounting for 7.6 million deaths (around 13% of all deaths) in 200...
ROLE OF SPEECH THERAPY WITH MAHESHWAR SUTRA AND PARENTAL SPIRITUAL COUNSELLING IN AUTISM: A CASE STUDY
A male child of 7 year old came to the general Ayurveda OPD in March 2013,with chief complaints of problem in speech and lack of social interaction. The child was irritable, aggressive and disobedient. On history takin...
INTERACTIVE POTENTIAL OF CLARITHROMYCIN IN RATS ADMINISTERED WITH GLICLAZIDE IN NORMAL AND DIABETIC CONDITIONS
To investigate the interaction between clarithromycin and gliclazide, the present study is designed in various animal models. Albino rats and rabbits were selected for the current study. The animals were suitably grouped...
A REVIEW ON AEGLE MARMELOS: A POTENTIAL MEDICINAL TREE
Since time immemorial, plants and their products have been the primary resource of food and medicines for mankind. Aegle marmelos commonly known as bael (or bel), belonging to the family Rutaceae, is a moderate sized, sl...