Synthesis and Pharmacological Evaluation of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a Cocaine Antagonist, in Rodents
Journal Title: The AAPS Journal - Year 2011, Vol 13, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-011-9274-9) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Nidhi Kaushal, Matthew J. Robson, Harsha Vinnakota, Sanju Narayanan, Bonnie A. Avery, Christopher R. McCurdy, Rae R. Matsumoto
Developmental toxicity of prenatal exposure to toluene
Organic solvents have become ubiquitous in our environment and are essential for industry. Many women of reproductive age are incresingly exposed to solvents such as toluene in occupational settings (ie, long-term, lowco...
Disposition of Human Recombinant Lubricin in Naive Rats and in a Rat Model of Post-traumatic Arthritis After Intra-articular or Intravenous Administration
We have recently demonstrated that intra-articular (IA) administration of human recombinant lubricin, LUB:1, significantly inhibited cartilage degeneration and pain in the rat meniscal tear model of post-traumatic arthri...
The influence of market exclusivity on drug availability and medical innovations
The interpretation and application of intellectual property laws is enormously complex in the pharmaceutical industry, with companies needing to obtain multiple patents to fully protect their innovations. While patents p...
Antibody Drug Conjugates: Nonclinical Safety Considerations
Antibody drug conjugates (ADCs) are biopharmaceutical molecules consisting of a cytotoxic small molecule covalently linked to a targeted protein carrier via a stable cleavable or noncleavable linker. The process of conju...
Scientific Considerations for Generic Synthetic Salmon Calcitonin Nasal Spray Products
Under the Abbreviated New Drug Application pathway, a proposed generic salmon calcitonin nasal spray is required to demonstrate pharmaceutical equivalence and bioequivalence to the brand-name counterpart or the reference...