Synthesis and Preliminary Evaluation of Danshensutetramethylpyrazine Derivatives
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2017, Vol 7, Issue 5
Abstract
In this study, a series of novel Danshensu-tetramethylpyrazine derivatives were synthesized, and their cardioprotective effects and water solubility in vitro were evaluated. The results illustrated that esterification at phenol hydroxyl group was superior to etherification in biological activity. The modification with short-chain fatty acids at the alcoholic hydroxyl group should be avoided. In addition, the introduction of amino acids to the phenol hydroxyl group and the alcoholic hydroxyl group may be a useful strategy for improving the water solubility. This work provides valuable information in structure-activity relationship for further development of DSS derivatives as cardioprotective agents.
Authors and Affiliations
Mingming Cai, Qingbin Cui, Luchen Shan, Xiaojing Zhang, Pei Yu
Keywords
Related Articles
- EP ID EP432682
- DOI -
- Views 118
- Downloads 0
Chemo-radiation in Small Cell Neuroendocrine Carcinoma Oesophagus: A Case Report
Primary small cell neuroendocrine carcinoma oesophagus is a very rare tumour, treated with radiotherapy and chemotherapy. A 55-year-old female presented with complaint of dysphagia, investigated and diagnosed as small ce...
Vascular Thoracic Fibrous Adipose Tissue (New Disease)
Indroduction The primary tumors of the chest wall are rare, about 2% of all cancers, and 50% are derived from soft tissue neoplasms, benign or malignant that arise at the level of the chest wall representing 2% of all ca...
Analysis of Prescribing Patterns of Antihypertensive and Antidiabetic Medications in Patients
Background Prescription of irrational drug is now a day’s a common practice globally; it can result in increase on morbidity, mortality and economic burden on society. Aims and Objective To study on drug prescribing patt...
Effects of Chicken Extract on the Serotonergic System of Mice Loaded with Restraint Stress
Chicken extract (CE), which is composed of water-soluble substances extracted from chicken by double boiling, could enhance mental efficiency and are helpful to the recovery from postpartum sickness and mental fatigue. B...
Prevalence of Overweight and Obesity in Urban and Rural Areas of Aligarh
Background Overweight and obesity are the major risk factors for a number of chronic diseases, including diabetes, cardiovascular diseases and cancer. There is a need to evaluate the burden of obesity in local population...