SYNTHESIS, ANTI-BACTERIAL, AND ANTI-FUNGAL ACTIVITIES OF SOME NOVEL N-SUBSTITUTED 2-(4-STYRYLPHENYL)-1H-BENZIMIDAZOLES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 2
Abstract
The synthesis of a series of novel substituted benzimidazole derivatives by the condensation of o-phenylenediamine (1) with 4-bromophenoxy acetic acid (2) and subsequent reactions of the benzimidazole with different electrophiles have been reported. The latter compounds were reacted with styrene following Heck Coupling reaction. The synthesized compounds were characterized by IR, 1H-NMR, Mass and Elemental analysis for their structures. All the synthesized compounds were tested for their potential anti-bacterial and anti-fungal activities. This exhibited some promising results towards testing organism in vitro.
Authors and Affiliations
Gund Radhu, Vaidya Dashrath
Keywords
Related Articles
- EP ID EP126181
- DOI 10.7897/2230-8407.050215
- Views 117
- Downloads 0
LEPA’S: TOPICAL APPLICATION OF AYURVEDA
The goal of medicine is to prevent the disease, restore health and suffering. Understanding and appropriately treating pain is an important component of this goal. Pain is universally recognized as a signal of disease or...
ASSESSMENT OF THE ACCEPTABILITY OF CONTRACEPTIVE USE AMONG THE WOMEN OF RURAL AND URBAN AREAS OF RAWALPINDI, PAKISTAN
Aim of the study was to document the prevalence of use of Contraceptives among the rural and urban areas of Rawalpindi, Pakistan. Specific objectives were to identify the percentage of women using contraceptive, to docum...
EFFECT OF PH AND TIME ON CALCIUM RELEASE FROM SOUND ENAMEL: AN ATOMIC SPECTROMETRIC ANALYSIS
Dental Caries is a disease of great concern which affects people of all races in all places, the exact etiology of caries though unknown; it is well established that the release of calcium and phosphate from hydroxyapati...
BENZIMIDAZOLES: THE LATEST INFORMATION ON BIOLOGICAL ACTIVITIES
Benzimidazole is a heterocyclic aromatic organic compound. It is an important pharmacophore and a privileged structure in medicinal chemistry. Benzimidazole and its derivatives play an important role in medical field wit...
SYNTHESIS, DOCKING STUDIES AND FREE RADICAL SCAVENGING ACTIVITY OF THE LINEAR TETRAPEPTIDE VFPF
A rational designing of the linear tetrapeptide Val-Phe-Pro-Phe (VFPF) was done and was synthesized by solution phase peptide synthesis. The solution phase synthesis of VFPF was carried out by using ethyl-3-dimethylamino...