Synthesis, characterisation and disease oriented preliminary anticancer in vitro screening of some novel pyrimidones
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 2
Abstract
Pyrimidones have been reported to possess significant biological activities, viz., fungicidal, bactericidal, hypnotic and anaesthetic activities. Substituted pyrimidones are also known to exhibit significant anticancer activities. The anticancer activities of the newly synthesized compounds were evaluated against human cell lines/panel namely Leukaemia, Non-Small Cell Lungs Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer, CNS Cancer Melanoma, Breast Cancer and Colon Cancer. Compounds exhibit moderate to high level of activities with cell lines. 1-Acidamide-3-aryl/H-1,3-dihydro-2-thioxo-2H,5H-pyrimidine-4,6-diones substituted compounds are synthesized. Their purity was ascertained by TLC and recrystallization methods and checked with the help of mixed melting points. These novel thiopyrimidones have been characterized by IR and NMR spectroscopic methods and screening was done for in vitro disease oriented primary anticancer activities. The screening revels good to moderate levels of activities. The anticancer activities were conducted by the Department of Health and Human Services, National Institute of Health, National Cancer Institute, Bethesda, Maryland.
Authors and Affiliations
Priyanka Singh, S. D. Sharma
Keywords
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- EP ID EP413966
- DOI 10.9790/5736-1102012124.
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