Synthesis, Characterization and Anticonvulsant Activity on Novel Thiourea Derivatives
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2014, Vol 2, Issue 4
Abstract
The present research work involves the synthesis of a series of N-Substituted Thiourea derivatives (T1- T3) by refluxing 8-(3-nitrophenoxy) octan-1-amine in THF (Tetrahydrofuran). The synthesized compounds were characterized by elemental analysis, FTIR, 1H-NMR, mass spectrum. All the synthesized compounds were screened for anti-convulsant activity by using Maximal electroshock seizure (MES) tests. Among the tested compounds, thiourea derivatives of T1 showed most potent activity and were afforded MES tests at 25 mg/kg, respectively.
Authors and Affiliations
Priya Kumar, Anjana Sharma, S. K. Gupta
Keywords
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