SYNTHESIS, CHARACTERIZATION AND BINDING PROPERTIES TOWARDS CT-DNA OF MIXED-LIGAND Cu(II) COMPLEX WITH 2-AMINOBENZONITRLE AND OCTANOATE ION
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 11
Abstract
A novel coordination complex of 2-aminobenzonitrile (ABN) and octanoate ion (OC) with Cu(II) metal ion has been prepared by using microwave irradiation. The molecular formula and the geometry of the complex have been deduced from elemental analysis, molar conductance, magnetic moment, electronic spectra, FT- IR spectra, cyclic voltammetry, thermal analysis and EPR spectra. The molar conductance value indicates that the complex is non-electrolyte (1:0) type. The electronic spectrum and the magnetic moment indicate the geometry of the complex is octahedral. FT-IR spectra show that 2-aminobenzonitrile is coordinated to the metal ion in a bidentate and octanoate ion in a monodentate manner. The metal-ligand covalency of Cu(II) complex has been arrived at from EPR spectrum. The antimicrobial activities of ligands and their Cu(II) complex were studied against the microorganisms, viz., staphylococcus aureus, streptococcus, Klebsiella, pseudomonas aeruginosa, salmonella typhi, Enterobacter, E. coli, C. albicans, Aspergillus flavus and Aspergillus niger by agar - well diffusion method. The complex shows potential activity against the bacteria and fungi as compared to the free ligands. The free radical scavenging activity of the complex and the ligands have been determined by measuring their interaction with the stable free radical DPPH. The complex has larger antioxidant activity as compared to the ligands. The DNA-binding properties of the free ligand ABN and its Cu(II) complex have been investigated by fluorescence measurements. The results suggest that ABN and its Cu(II) complex both bind to DNA via an intercalative binding mode and the affinity for DNA is more strong in case of Cu(II) complex when compared with ABN.
Authors and Affiliations
R. Govindharaju et al.
Keywords
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- EP ID EP665746
- DOI 10.13040/IJPSR.0975-8232.10(11).5137-45
- Views 107
- Downloads 0
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