SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDY OF MANNICH BASES AND THEIR COPPER (II) COMPLEXES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: The present study is focused on the synthesis of novel Mannich bases and their metal complexes, and to characterize them by physical, chemical and biological methods. Mannich bases, 2-(piperazin-1-yl(thiophen-2-yl)methyl)hydrazinecarboxamide (PTMHC), 2-(piperazin-1-yl(thiophen-2-yl)methyl)hydrazinecarbothioamide (PTMHCT), and 2-((4-methylpiperazin-1-yl)(thiophen-2-yl)methyl)hydrazinecarboxamide (MPTMHC) and 2-((4-methylpiperazin-1-yl)(thiophen-2-yl)methyl)hydrazinecarbothioamide (MPTMHCT), were prepared by Mannich condensation method.Methods: The compounds and complexes were prepared by known literature methods. Characterizations were carried out through physical methods such as elemental analyses, melting point and TLC. IR, 1H NMR, [13]C NMR and Mass spectral studies were carried out to characterize the ligands. The methods like EPR, magnetic susceptibility measurements, conductance measurements and thermal analysis were carried out for complexes besides the UV-Vis and IR spectral studies. Anti-cancer activity of synthesized ligands was performed using human lung and colon cancer cell lines.Results: Eight compounds have been prepared and characterized. Four among the eight compounds were used as ligands for the preparation of metal complexes. The results of physical and chemical methods show all the complexes act as bidentate ligands. The coordination with the metal ion takes place through N, S and O atoms. The results of molar conductivity and magnetic susceptibility measurements reveal the electrolytic and non-electrolytic nature of the metal complexes. EPR and TG-DTA studies also support the other spectral data.Conclusions: Copper (II) complexes of PTMHC, PTMHCT, MPTMHC, and MPTMHCT were prepared and their structures were determined. The anti-cancer activity of the synthesized ligands and their complexes was evaluated. The synthesized novel ligands of Mannich bases can serve as a potential anti-cancer agent.Â
Authors and Affiliations
Syed Ali Padusha, T. H. Mohamed Ahadu Shareef
Keywords
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