Synthesis, Characterization and Pharmacological Evaluation of Novel Mannich bases of Thienopyrimidine Derivatives
Journal Title: Scholars Academic Journal of Pharmacy - Year 2016, Vol 5, Issue 4
Abstract
Thienopyrimidines has received considerable attention as they are endowed with variety of biological activities and have wide range of therapeutic properties. Thienopyrimidines, the structural analogues of biogenic purine class, has high significant in field of pharmaceutical and biotechnological sciences, with wide spectrum of biological activities. A series thienopyrimidines can be easily synthesized by Gewald reaction. The first step of this multicomponent reaction is the Knoevenagel-Cope condensation of carbonyl compound (ketone or aldehyde) with an activated nitrile (α-cyanoester), yielding an α,β– unsaturated nitrile. This intermediate is then thiolated at the methylene group by elemental sulfur, followed by an intramolecular cyclization yielding a polysubstituted-2-aminothiophene.The structure of compounds were characterized by 1H-NMR, IR and mass spectral analysis, and evaluated for their anti-inflammatory activity by carrageen induced paw oedema method and standard drug used for anti-inflammatory activity is Diclofenac Sodium. Keywords:Gewald reaction, 2-aminothiophene, thieno [2, 3-d] pyrimidine derivatives, anti inflammatory activity.
Authors and Affiliations
D. Rajendra, Syed Asma, Dr K Vijaya, G Kalyani
Keywords
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