SYNTHESIS, CHARACTERIZATION AND STUDY OF ANTIMICROBIAL ACTIVITY OF 2,6-DITERTIARY BUTYL-1,4-BENZOQUINONE HYDRAZONES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 8
Abstract
Four 2,6-di-tert-butyl-1,4-benzoquinone hydrazones have been synthesized viz. A1, A2, A3 and A4. The purity was checked using HPLC. These compounds were characterized by FTIR and H1-NMR and they shows a prominent absorption of -(C=N-) in FTIR. It also shows a common peak of oleifinic proton at 6.50 Hz. These hydrazones were tested for their antimicrobial activity against Gram +ve and Gram –ve bacteria. A3 was found to be active at a minimum concentration of 50 μg•mL–1 where as A2 was inactive.
Authors and Affiliations
Anees Pangal, Khursheed Ahmed, Sajid Shaikh
Keywords
Related Articles
- EP ID EP93500
- DOI 10.7897/2230-8407.04834
- Views 88
- Downloads 0
AN OVERVIEW: ROLE OF PROCESS VALIDATION IN TABLETS
The purpose of this work is to present an introduction and general overview on process validation of pharmaceutical manufacturing process especially tablet manufacturing process. Validation is the documented act of demon...
HEALTHY LIVING WITH NUTRACEUTICALS
Now a day every person wants to live the healthy life. Synthetic medicines are having some certain drawbacks. So nutraceuticals will definitely play promising and unique way of safer medicines. Nature is one of the most...
FORMULATION AND EVALUATION OF VENLAFAXINE HYDROCHLORIDE MUCOADHESIVE BUCCAL TABLETS
The present study involves the formulation and evaluation of buccal tablets of venlafaxine hydrochloride, an antidepressant drug to circumvent the first pass metabolism. Buccal route is excellent for the systemic deliver...
ISOLATION AND CHARACTERIZATION OF MURRAYA PANICULATA ETHANOL SEED EXTRACT FOR THEIR ANTIOXIDANT COMPONENTS
The objective of this study is isolation and characterization of Murraya paniculata ethanol seed extract for their antioxidant components. The 50 % ethanol seed extract of Murraya paniculata was screened for phytochemica...
FORMULATION AND EVALUATION OF INDOMETHACIN MICROSPHERES FOR COLONIC DRUG DELIVERY SYSTEM
Colon specific drug delivery has gained increased importance not just for delivery of drug for the treatment of local diseases, associated with the colon but also potential site for systemic delivery of therapeutic drug....