Synthesis of 1,8-Napthyridine derivatives and their evaluation as possible antiepileptic agents
Journal Title: Journal of Pharmacology and Biomedicine - Year 2017, Vol 1, Issue 1
Abstract
Aminopropyloxy derivatives of 1,8-naphthyridines have been synthesized using the principle of Conrad-Limpach synthesis of quinolines. The hydroxy group at 2- position of the naphthyridine ring was converted to the corresponding epoxypropane ether derivative by etherification with epichlorhydrin. The epoxy ether was then aminated in presence of KOH with the corresponding amines to obtain the aminopropyloxy derivatives. The compounds were tested for anti convulsant action at dose of 150mg/Kg relative to diazepam (5mg/Kg) by prevention of PTZ-induced seizures in mice.
Authors and Affiliations
Brijeshkunvar Mishra
Keywords
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Synthesis of 1,8-Napthyridine derivatives and their evaluation as possible antiepileptic agents
Aminopropyloxy derivatives of 1,8-naphthyridines have been synthesized using the principle of Conrad-Limpach synthesis of quinolines. The hydroxy group at 2- position of the naphthyridine ring was converted to the corres...